Abstract
Polyketide synthase 9 (PKS9) is one of the 15 identified polyketide synthase (PKS) genes in Fusarium graminearum. The gene is coregulated
along with five neighboring genes by a single transcription factor (TF). An overexpression of the transcription factor led to
production of three novel fusarielins, F, G and H.
Fusarielin H is the predicted end product of PKS9 gene cluster, as it is the only detectable fusarielin by the wild type strain and
the most abundant fusarielin produced by the over-expressed mutant. In order to examine the biosynthetic pathway of the
fusarielins produced by this cluster in Fusarium graminearum., deletion mutant of each gene was created in the overexpressed
mutant by targeted gene replacemen
along with five neighboring genes by a single transcription factor (TF). An overexpression of the transcription factor led to
production of three novel fusarielins, F, G and H.
Fusarielin H is the predicted end product of PKS9 gene cluster, as it is the only detectable fusarielin by the wild type strain and
the most abundant fusarielin produced by the over-expressed mutant. In order to examine the biosynthetic pathway of the
fusarielins produced by this cluster in Fusarium graminearum., deletion mutant of each gene was created in the overexpressed
mutant by targeted gene replacemen
| Original language | Danish |
|---|---|
| Publication date | May 2013 |
| Publication status | Published - May 2013 |
| Event | 8.th Danish Conference on Biotechnology and Molecular Biology: Food Biotechnology and Nutrigenomics - Hotel Munkebjerg, Vejle, Denmark Duration: 30 May 2013 → 31 May 2013 |
Conference
| Conference | 8.th Danish Conference on Biotechnology and Molecular Biology |
|---|---|
| Location | Hotel Munkebjerg |
| Country/Territory | Denmark |
| City | Vejle |
| Period | 30/05/2013 → 31/05/2013 |