A Case of Penile Metastasis from Prostate Cancer, Identified by 68Ga-PSMA PET/CT, Mimicking Peyronie’s Disease: A Diagnostic Challenge

Farid Gossili*, Niels Christian Langkilde, Helle D. Zacho

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

A 70-year-old man with high-risk prostate cancer (PCa) received radiation therapy and androgen deprivation therapy (ADT). The patient developed penile tenderness, compatible with Peyronie’s disease upon physical examination. An ultrasound revealed a matching hypoechoic plaque and a thrombus in the vena dorsalis profunda, which were treated with anticoagulants. A follow-up ultrasound showed no abnormalities. Despite the use of analgesics, the patient suffered from persistent pain, later accompanied by an increasing PSA level of up to 7.5 ng/mL, despite ADT. 68Ga-PSMA PET/CT showed a PSMA uptake consistent with PCa penile metastasis. Due to severe pain and the presence of metastatic PCa, the patient was referred for penectomy. Histopathological analysis confirmed metastases originating from the PCa. This case underscores the importance of 68Ga-PSMA PET/CT in diagnosing PCa metastases and vigilance towards urogenital symptoms as potential indicators of metastases, despite the rarity of penile metastases.

Original languageEnglish
Article number2509
JournalDiagnostics
Volume13
Issue number15
ISSN2075-4418
DOIs
Publication statusPublished - 27 Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • Ga-PSMA PET/CT
  • penile metastases
  • Peyronie’s disease
  • prostate cancer

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