TY - JOUR
T1 - Association between the accumulation of elevated serum γ-glutamyltransferase level and risk of atrial fibrillation
T2 - a nationwide cohort study
AU - Jeon, Won Kyeong
AU - Lee, So-Ryoung
AU - Han, Kyung-Do
AU - Choi, Eue-Keun
AU - Oh, Seil
AU - Lip, Gregory Y. H.
N1 - © 2023. Springer Nature Limited.
PY - 2023/8/23
Y1 - 2023/8/23
N2 - Atrial fibrillation (AF) is the most common cardiac arrhythmia. The association between AF and γ-Glutamyltransferase (GGT) was not fully established. This study demonstrated the independent association of cumulative GGT score and AF incidence with the dose-response relationship. Using the Korean National Health Insurance Corporation database, adult subjects who had 4 consecutive annual health examinations from 2009 to 2012 were enrolled. A cumulative GGT score was calculated as the cumulative number of the highest GGT quartile amongst four examinations (0-4 times). A multivariable Cox proportional hazards regression analysis was performed. Among a total of 3,500,847 people included, AF was developed in 27,752 people (0.793%) during a median of 8.0 years of follow up. The incidence rate of AF and adjusted hazard ratio were increased by a stepwise manner in the higher quartile group and cumulative GGT score group. In subgroup analysis, this trend was more prominent in the elderly, people without hypertension, non-obese people, and people without any four comorbidities (diabetes mellitus, hypertension, dyslipidemia, and obesity). Our results suggest multiple accumulation of elevated GGT levels in health examination might be a useful marker for risk stratification of AF development, especially in the elderly and healthy population.
AB - Atrial fibrillation (AF) is the most common cardiac arrhythmia. The association between AF and γ-Glutamyltransferase (GGT) was not fully established. This study demonstrated the independent association of cumulative GGT score and AF incidence with the dose-response relationship. Using the Korean National Health Insurance Corporation database, adult subjects who had 4 consecutive annual health examinations from 2009 to 2012 were enrolled. A cumulative GGT score was calculated as the cumulative number of the highest GGT quartile amongst four examinations (0-4 times). A multivariable Cox proportional hazards regression analysis was performed. Among a total of 3,500,847 people included, AF was developed in 27,752 people (0.793%) during a median of 8.0 years of follow up. The incidence rate of AF and adjusted hazard ratio were increased by a stepwise manner in the higher quartile group and cumulative GGT score group. In subgroup analysis, this trend was more prominent in the elderly, people without hypertension, non-obese people, and people without any four comorbidities (diabetes mellitus, hypertension, dyslipidemia, and obesity). Our results suggest multiple accumulation of elevated GGT levels in health examination might be a useful marker for risk stratification of AF development, especially in the elderly and healthy population.
KW - Adult
KW - Aged
KW - Humans
KW - Atrial Fibrillation/epidemiology
KW - Cardiac Conduction System Disease
KW - Cohort Studies
KW - gamma-Glutamyltransferase
KW - Hypertension/epidemiology
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85168620055&partnerID=8YFLogxK
U2 - 10.1038/s41598-023-40689-2
DO - 10.1038/s41598-023-40689-2
M3 - Journal article
C2 - 37612304
SN - 2045-2322
VL - 13
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13771
ER -