Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus A case report

Mona Kjaerboel Kristiansen; Isa Niemann; Jacob Christian Lindegaard; Mette Christiansen; Mette Warming Joergensen; Ida Vogel; Dorte Launholt Lildballe; Lone Sunde

doi:10.1097/MD.0000000000004721

Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus A case report

Mona Kjaerboel Kristiansen^*, Isa Niemann, Jacob Christian Lindegaard, Mette Christiansen, Mette Warming Joergensen, Ida Vogel, Dorte Launholt Lildballe, Lone Sunde

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Background: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. Results: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. Conclusion: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.

Original language	English
Article number	e4721
Journal	Medicine
Volume	95
Issue number	37
ISSN	0025-7974
DOIs	https://doi.org/10.1097/MD.0000000000004721
Publication status	Published - 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.

Keywords

Cell-free DNA
Choriocarcinoma
Coexistent pregnancy
Noninvasive diagnostics
Trophoblastic neoplasia

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10.1097/MD.0000000000004721

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Cite this

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title = "Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus A case report",

abstract = "Background: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. Results: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. Conclusion: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.",

keywords = "Cell-free DNA, Choriocarcinoma, Coexistent pregnancy, Noninvasive diagnostics, Trophoblastic neoplasia",

author = "Kristiansen, {Mona Kjaerboel} and Isa Niemann and Lindegaard, {Jacob Christian} and Mette Christiansen and Joergensen, {Mette Warming} and Ida Vogel and Lildballe, {Dorte Launholt} and Lone Sunde",

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doi = "10.1097/MD.0000000000004721",

language = "English",

volume = "95",

journal = "Medicine",

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T1 - Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus A case report

AU - Kristiansen, Mona Kjaerboel

AU - Niemann, Isa

AU - Lindegaard, Jacob Christian

AU - Christiansen, Mette

AU - Joergensen, Mette Warming

AU - Vogel, Ida

AU - Lildballe, Dorte Launholt

AU - Sunde, Lone

PY - 2016

Y1 - 2016

N2 - Background: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. Results: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. Conclusion: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.

AB - Background: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. Results: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. Conclusion: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.

KW - Cell-free DNA

KW - Choriocarcinoma

KW - Coexistent pregnancy

KW - Noninvasive diagnostics

KW - Trophoblastic neoplasia

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U2 - 10.1097/MD.0000000000004721

DO - 10.1097/MD.0000000000004721

M3 - Journal article

C2 - 27631219

AN - SCOPUS:84991661885

SN - 0025-7974

VL - 95

JO - Medicine

JF - Medicine

IS - 37

M1 - e4721

ER -

Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus A case report

Abstract

Bibliographical note

Keywords

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