TY - JOUR
T1 - Diarrhoea of unknown cause: medical treatment in a stepwise manner: Management of Idiopathic Diarrhoea Based on Experience of Step-Up Medical Treatment
AU - Jansson-Rehnberg, Ann-Sofie
AU - Drewes, Asbjørn Mohr
AU - Sponheim, Jon
AU - Borgfelt, Christer
AU - Münch, Andreas
AU - Graf, Wilhelm
AU - Simrén, Magnus
AU - Lindberg, Greger
AU - Hellström, Per M.
PY - 2024/5
Y1 - 2024/5
N2 - The basic principle for the treatment of idiopathic diarrhoea (functional diarrhoea K59.1) is to delay transit through the gut in order to promote the absorption of electrolytes and water. Under mild conditions, bulking agents may suffice. With increasing severity, antidiarrhoeal pharmaceuticals may be added in a stepwise manner. In diarrhoea of unknown aetiology, peripherally-acting opioid receptor agonists, such as loperamide, are first-line treatment and forms the pharmaceutical basis of antidiarrheal treatment. As second-line treatment opium drops have an approved indication for severe diarrhoea when other treatment options fail. Beyond this, various treatment options are built on experience with more advanced treatments using clonidine, octreotide, as well as GLP-1 and GLP-2 analogs which require specialist knowledge the field.
AB - The basic principle for the treatment of idiopathic diarrhoea (functional diarrhoea K59.1) is to delay transit through the gut in order to promote the absorption of electrolytes and water. Under mild conditions, bulking agents may suffice. With increasing severity, antidiarrhoeal pharmaceuticals may be added in a stepwise manner. In diarrhoea of unknown aetiology, peripherally-acting opioid receptor agonists, such as loperamide, are first-line treatment and forms the pharmaceutical basis of antidiarrheal treatment. As second-line treatment opium drops have an approved indication for severe diarrhoea when other treatment options fail. Beyond this, various treatment options are built on experience with more advanced treatments using clonidine, octreotide, as well as GLP-1 and GLP-2 analogs which require specialist knowledge the field.
KW - Absorption
KW - alpha2-receptor
KW - cholestyramine
KW - fiber
KW - opioid
UR - http://www.scopus.com/inward/record.url?scp=85185490092&partnerID=8YFLogxK
U2 - 10.1080/00365521.2024.2313061
DO - 10.1080/00365521.2024.2313061
M3 - Review article
C2 - 38343268
SN - 0036-5521
VL - 59
SP - 543
EP - 546
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 5
ER -