Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study

Mauro Serafini; Paula Jakszyn; Leila Luján-Barroso; Antonio Agudo; H Bas Bueno-de-Mesquita; Fränzel J B van Duijnhoven; Mazda Jenab; Carmen Navarro; Domenico Palli; Heiner Boeing; Peter Wallström; Sara Regnér; Mattijs E Numans; Fatima Carneiro; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Sophie Morois; Sara Grioni; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; José Ramon Quirós; Esther Molina-Montes; Jose M Huerta Castaño; Aurelio Barricarte; Pilar Amiano; Kay-Tee Khaw; Nicholas Wareham; Naomi E Allen; Timothy J Key; Suzanne M Jeurnink; Petra Hm Peeters; Christina Bamia; Elisabeth Valanou; Antonia Trichopoulou; Rudolf Kaaks; Annekatrin Lukanova; Manuela M Bergmann; Björn Lindkvist; Roger Stenling; Ingegerd Johansson; Christina C Dahm; Kim Overvad; Majken Jensen; Anja Olsen; Anne Tjonneland; Eiliv Lund; Sabina Rinaldi; Dominique Michaud; Traci Mouw; Elio Riboli; Carlos A González

doi:10.1002/ijc.27347

Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study

Mauro Serafini, Paula Jakszyn, Leila Luján-Barroso, Antonio Agudo, H Bas Bueno-de-Mesquita, Fränzel J B van Duijnhoven, Mazda Jenab, Carmen Navarro, Domenico Palli, Heiner Boeing, Peter Wallström, Sara Regnér, Mattijs E Numans, Fatima Carneiro, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sophie Morois, Sara Grioni, Salvatore Panico, Rosario TuminoCarlotta Sacerdote, José Ramon Quirós, Esther Molina-Montes, Jose M Huerta Castaño, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Nicholas Wareham, Naomi E Allen, Timothy J Key, Suzanne M Jeurnink, Petra Hm Peeters, Christina Bamia, Elisabeth Valanou, Antonia Trichopoulou, Rudolf Kaaks, Annekatrin Lukanova, Manuela M Bergmann, Björn Lindkvist, Roger Stenling, Ingegerd Johansson, Christina C Dahm, Kim Overvad, Majken Jensen, Anja Olsen, Anne Tjonneland, Eiliv Lund, Sabina Rinaldi, Dominique Michaud, Traci Mouw, Elio Riboli, Carlos A González

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary Total Antioxidant Capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric Reducing Antioxidant Potential, (FRAP) and Total Radical-Trapping Antioxidant Parameter, (TRAP), measuring reducing and chain breaking antioxidant capacity, were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and non cardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the 5(th) quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend

Original language	English
Journal	International Journal of Cancer
Volume	131
Pages (from-to)	E544-54
Number of pages	11
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.27347
Publication status	Published - 2012
Externally published	Yes

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Serafini, M., Jakszyn, P., Luján-Barroso, L., Agudo, A., Bueno-de-Mesquita, H. B., van Duijnhoven, F. J. B., Jenab, M., Navarro, C., Palli, D., Boeing, H., Wallström, P., Regnér, S., Numans, M. E., Carneiro, F., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Morois, S., Grioni, S., Panico, S., ... González, C. A. (2012). Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study. International Journal of Cancer, 131, E544-54. https://doi.org/10.1002/ijc.27347

@article{20cb6a60e6b343b1a1486ff6cadc1f52,

title = "Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study",

abstract = "A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary Total Antioxidant Capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric Reducing Antioxidant Potential, (FRAP) and Total Radical-Trapping Antioxidant Parameter, (TRAP), measuring reducing and chain breaking antioxidant capacity, were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and non cardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the 5(th) quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend",

author = "Mauro Serafini and Paula Jakszyn and Leila Luj{\'a}n-Barroso and Antonio Agudo and Bueno-de-Mesquita, {H Bas} and {van Duijnhoven}, {Fr{\"a}nzel J B} and Mazda Jenab and Carmen Navarro and Domenico Palli and Heiner Boeing and Peter Wallstr{\"o}m and Sara Regn{\'e}r and Numans, {Mattijs E} and Fatima Carneiro and Marie-Christine Boutron-Ruault and Fran{\c c}oise Clavel-Chapelon and Sophie Morois and Sara Grioni and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and Quir{\'o}s, {Jos{\'e} Ramon} and Esther Molina-Montes and {Huerta Casta{\~n}o}, {Jose M} and Aurelio Barricarte and Pilar Amiano and Kay-Tee Khaw and Nicholas Wareham and Allen, {Naomi E} and Key, {Timothy J} and Jeurnink, {Suzanne M} and Peeters, {Petra Hm} and Christina Bamia and Elisabeth Valanou and Antonia Trichopoulou and Rudolf Kaaks and Annekatrin Lukanova and Bergmann, {Manuela M} and Bj{\"o}rn Lindkvist and Roger Stenling and Ingegerd Johansson and Dahm, {Christina C} and Kim Overvad and Majken Jensen and Anja Olsen and Anne Tjonneland and Eiliv Lund and Sabina Rinaldi and Dominique Michaud and Traci Mouw and Elio Riboli and Gonz{\'a}lez, {Carlos A}",

note = "Copyright {\textcopyright} 2011 UICC.",

year = "2012",

doi = "10.1002/ijc.27347",

language = "English",

volume = "131",

pages = "E544--54",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley",

}

Serafini, M, Jakszyn, P, Luján-Barroso, L, Agudo, A, Bueno-de-Mesquita, HB, van Duijnhoven, FJB, Jenab, M, Navarro, C, Palli, D, Boeing, H, Wallström, P, Regnér, S, Numans, ME, Carneiro, F, Boutron-Ruault, M-C, Clavel-Chapelon, F, Morois, S, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, Quirós, JR, Molina-Montes, E, Huerta Castaño, JM, Barricarte, A, Amiano, P, Khaw, K-T, Wareham, N, Allen, NE, Key, TJ, Jeurnink, SM, Peeters, PH, Bamia, C, Valanou, E, Trichopoulou, A, Kaaks, R, Lukanova, A, Bergmann, MM, Lindkvist, B, Stenling, R, Johansson, I, Dahm, CC, Overvad, K, Jensen, M, Olsen, A, Tjonneland, A, Lund, E, Rinaldi, S, Michaud, D, Mouw, T, Riboli, E & González, CA 2012, 'Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study', International Journal of Cancer, vol. 131, pp. E544-54. https://doi.org/10.1002/ijc.27347

TY - JOUR

T1 - Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study

AU - Serafini, Mauro

AU - Jakszyn, Paula

AU - Luján-Barroso, Leila

AU - Agudo, Antonio

AU - Bueno-de-Mesquita, H Bas

AU - van Duijnhoven, Fränzel J B

AU - Jenab, Mazda

AU - Navarro, Carmen

AU - Palli, Domenico

AU - Boeing, Heiner

AU - Wallström, Peter

AU - Regnér, Sara

AU - Numans, Mattijs E

AU - Carneiro, Fatima

AU - Boutron-Ruault, Marie-Christine

AU - Clavel-Chapelon, Françoise

AU - Morois, Sophie

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Quirós, José Ramon

AU - Molina-Montes, Esther

AU - Huerta Castaño, Jose M

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E

AU - Key, Timothy J

AU - Jeurnink, Suzanne M

AU - Peeters, Petra Hm

AU - Bamia, Christina

AU - Valanou, Elisabeth

AU - Trichopoulou, Antonia

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Bergmann, Manuela M

AU - Lindkvist, Björn

AU - Stenling, Roger

AU - Johansson, Ingegerd

AU - Dahm, Christina C

AU - Overvad, Kim

AU - Jensen, Majken

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Lund, Eiliv

AU - Rinaldi, Sabina

AU - Michaud, Dominique

AU - Mouw, Traci

AU - Riboli, Elio

AU - González, Carlos A

PY - 2012

Y1 - 2012

N2 - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary Total Antioxidant Capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric Reducing Antioxidant Potential, (FRAP) and Total Radical-Trapping Antioxidant Parameter, (TRAP), measuring reducing and chain breaking antioxidant capacity, were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and non cardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the 5(th) quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend

AB - A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary Total Antioxidant Capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35-70 years old, were recruited largely between 1992 and 1998. Ferric Reducing Antioxidant Potential, (FRAP) and Total Radical-Trapping Antioxidant Parameter, (TRAP), measuring reducing and chain breaking antioxidant capacity, were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest quintile). The association was observed for both cardia and non cardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the 5(th) quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for trend

U2 - 10.1002/ijc.27347

DO - 10.1002/ijc.27347

M3 - Journal article

SN - 0020-7136

VL - 131

SP - E544-54

JO - International Journal of Cancer

JF - International Journal of Cancer

ER -

Dietary total antioxidant capacity and gastric cancer risk in the european prospective investigation into cancer and nutrition study

Abstract

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