TY - JOUR
T1 - Does age affect prognosis in salivary gland carcinoma patients?
T2 - A national Danish study
AU - Bjørndal, Kristine
AU - Larsen, Stine R
AU - Therkildsen, Marianne H
AU - Kristensen, Claus A
AU - Charabi, Birgitte
AU - Andersen, Elo
AU - Overgaard, Jens
AU - Schytte, Sten
AU - Pedersen, Henrik B
AU - Andersen, Lisbeth J
AU - Johansen, Jørgen
AU - Godballe, Christian
AU - Danish Head and Neck Cancer Group (DAHANCA) and Academy of Geriatric Cancer Research (AgeCare)
PY - 2016
Y1 - 2016
N2 - Aim To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years). Methods From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database. Results The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade. Conclusions Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.
AB - Aim To compare incidence, histology, treatment modalities, disease stages, and outcome in elderly patients (≥70 years) compared to younger (<70 years). Methods From the national Danish salivary gland carcinoma database, 871 patients diagnosed with a primary salivary gland carcinoma from January 1990 to December 2005 were identified. Variables necessary for statistical analyses were extracted from the database. Results The younger patients have a significantly better crude, disease-specific and recurrence-free survival than the elderly ones. In univariate analysis, significantly more patients in the young group were WHO performance status 0 and in disease stage I + II, and they presented with significantly more histological low grade tumors. In multivariate analysis, chronological age seemed to be of no prognostic significance to salivary gland carcinoma patients as opposed to performance status, disease stage and histological grade. Conclusions Salivary gland carcinoma patients over the age of 70 years have a poor prognosis compared to younger patients, which can be explained by higher disease stages, more histological high grade subtypes and a poorer performance status at the time of diagnosis.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-84956574011&origin=inward&txGid=03EB75B4FE440F5A345F107F454ED6B1.wsnAw8kcdt7IPYLO0V48gA%3a622#
U2 - 10.3109/0284186X.2015.1114671
DO - 10.3109/0284186X.2015.1114671
M3 - Journal article
C2 - 26825002
SN - 0284-186X
VL - 55
SP - 19
EP - 22
JO - Acta Oncologica
JF - Acta Oncologica
IS - Suppl 1
ER -