Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

Celina Pihl*, Katrine Togsverd-Bo, Flemming Andersen, Merete Haedersdal, Peter Bjerring, Catharina Margrethe Lerche

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
82 Downloads (Pure)

Abstract

Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.

Original languageEnglish
Article number3684
JournalCancers
Volume13
Issue number15
ISSN2072-6694
DOIs
Publication statusPublished - 22 Jul 2021

Keywords

  • Cancer
  • Cancer prevention
  • Keratinocyte carcinoma
  • Mechanism of action
  • Photocarcinogenesis
  • Phytochemicals
  • Skin
  • Skin cancer
  • Ultraviolet radiation

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