TY - JOUR
T1 - Keratinocyte Carcinoma and Photoprevention
T2 - The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins
AU - Pihl, Celina
AU - Togsverd-Bo, Katrine
AU - Andersen, Flemming
AU - Haedersdal, Merete
AU - Bjerring, Peter
AU - Lerche, Catharina Margrethe
PY - 2021/7/22
Y1 - 2021/7/22
N2 - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.
AB - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.
KW - Cancer
KW - Cancer prevention
KW - Keratinocyte carcinoma
KW - Mechanism of action
KW - Photocarcinogenesis
KW - Phytochemicals
KW - Skin
KW - Skin cancer
KW - Ultraviolet radiation
UR - http://www.scopus.com/inward/record.url?scp=85110630674&partnerID=8YFLogxK
U2 - 10.3390/cancers13153684
DO - 10.3390/cancers13153684
M3 - Review article
C2 - 34359586
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 15
M1 - 3684
ER -