NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry

Peter L. Graversen; Katra Hadji-Turdeghal; Jacob Eifer Møller; Niels Eske Bruun; Hicham Laghmoch; Andreas Dalsgaard Jensen; Jeppe K. Petersen; Henning Bundgaard; Kasper Iversen; Jonas A. Povlsen; Claus Moser; Morten Smerup; Hanne Sortsøe Jensen; Peter Søgaard; Jannik Helweg-Larsen; Daniel Faurholt-Jepsen; Lauge Østergaard; Lars Køber; Emil L. Fosbøl

doi:10.1016/j.ahj.2023.11.018

NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry

Peter L. Graversen^*, Katra Hadji-Turdeghal, Jacob Eifer Møller, Niels Eske Bruun, Hicham Laghmoch, Andreas Dalsgaard Jensen, Jeppe K. Petersen, Henning Bundgaard, Kasper Iversen, Jonas A. Povlsen, Claus Moser, Morten Smerup, Hanne Sortsøe Jensen, Peter Søgaard, Jannik Helweg-Larsen, Daniel Faurholt-Jepsen, Lauge Østergaard, Lars Køber, Emil L. Fosbøl

^*Corresponding author for this work

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Abstract

AIMS: The NatIonal Danish endocarditis stUdieS (NIDUS) registry aims to investigate the mechanisms contributing to the increasing incidence of infective endocarditis (IE) and to discover risk factors associated to the course, treatment and clinical outcomes of the disease.

METHODS: The NIDUS registry was created to investigate a nationwide unselected group of patients hospitalized for IE. The National Danish healthcare registries have been queried for validated IE diagnosis codes (International Classification of Disease, 10th edition [ICD-10]: DI33, DI38, and DI398). Subsequently, a team of 28 healthcare professionals, including experts in endocarditis, will systematically review and evaluate all identified patient records using the modified Duke Criteria and the 2015 European Society of Cardiology modified diagnostic criteria. The registry will contain all cases with definite or possible IE found in primary data sources in Denmark between January 1, 2016, and December 31, 2021. We will gather individual patient data, such as clinical, microbiological, and echocardiographic characteristics, treatment regimens, and clinical outcomes. A digital data collection form will be used to the gathering of data. A sample of approximately 4,300 individual patients will be evaluated using primary data sources.

CONCLUSIONS AND PERSPECTIVES: The NIDUS registry will be the first comprehensive nationwide IE registry, contributing critical knowledge about the course, treatment, and clinical outcomes of the disease. Additionally, it will significantly aid in identifying areas in which future research is needed.

Original language	English
Journal	American Heart Journal
Volume	268
Pages (from-to)	80-93
Number of pages	14
ISSN	0002-8703
DOIs	https://doi.org/10.1016/j.ahj.2023.11.018
Publication status	Published - Feb 2024

Bibliographical note

Keywords

Denmark/epidemiology
Echocardiography
Endocarditis, Bacterial/diagnosis
Endocarditis/diagnosis
Humans
Registries

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10.1016/j.ahj.2023.11.018Licence: CC BY 4.0

Graversen et al. (2024). NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registryFinal published version, 911 KBLicence: CC BY 4.0

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Graversen, P. L., Hadji-Turdeghal, K., Møller, J. E., Bruun, N. E., Laghmoch, H., Jensen, A. D., Petersen, J. K., Bundgaard, H., Iversen, K., Povlsen, J. A., Moser, C., Smerup, M., Jensen, H. S., Søgaard, P., Helweg-Larsen, J., Faurholt-Jepsen, D., Østergaard, L., Køber, L., & Fosbøl, E. L. (2024). NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry. American Heart Journal, 268, 80-93. https://doi.org/10.1016/j.ahj.2023.11.018

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title = "NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry",

abstract = "AIMS: The NatIonal Danish endocarditis stUdieS (NIDUS) registry aims to investigate the mechanisms contributing to the increasing incidence of infective endocarditis (IE) and to discover risk factors associated to the course, treatment and clinical outcomes of the disease.METHODS: The NIDUS registry was created to investigate a nationwide unselected group of patients hospitalized for IE. The National Danish healthcare registries have been queried for validated IE diagnosis codes (International Classification of Disease, 10th edition [ICD-10]: DI33, DI38, and DI398). Subsequently, a team of 28 healthcare professionals, including experts in endocarditis, will systematically review and evaluate all identified patient records using the modified Duke Criteria and the 2015 European Society of Cardiology modified diagnostic criteria. The registry will contain all cases with definite or possible IE found in primary data sources in Denmark between January 1, 2016, and December 31, 2021. We will gather individual patient data, such as clinical, microbiological, and echocardiographic characteristics, treatment regimens, and clinical outcomes. A digital data collection form will be used to the gathering of data. A sample of approximately 4,300 individual patients will be evaluated using primary data sources.CONCLUSIONS AND PERSPECTIVES: The NIDUS registry will be the first comprehensive nationwide IE registry, contributing critical knowledge about the course, treatment, and clinical outcomes of the disease. Additionally, it will significantly aid in identifying areas in which future research is needed.",

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author = "Graversen, {Peter L.} and Katra Hadji-Turdeghal and M{\o}ller, {Jacob Eifer} and Bruun, {Niels Eske} and Hicham Laghmoch and Jensen, {Andreas Dalsgaard} and Petersen, {Jeppe K.} and Henning Bundgaard and Kasper Iversen and Povlsen, {Jonas A.} and Claus Moser and Morten Smerup and Jensen, {Hanne Sorts{\o}e} and Peter S{\o}gaard and Jannik Helweg-Larsen and Daniel Faurholt-Jepsen and Lauge {\O}stergaard and Lars K{\o}ber and Fosb{\o}l, {Emil L.}",

year = "2024",

month = feb,

doi = "10.1016/j.ahj.2023.11.018",

language = "English",

volume = "268",

pages = "80--93",

journal = "American Heart Journal",

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Graversen, PL, Hadji-Turdeghal, K, Møller, JE, Bruun, NE, Laghmoch, H, Jensen, AD, Petersen, JK, Bundgaard, H, Iversen, K, Povlsen, JA, Moser, C, Smerup, M, Jensen, HS , Søgaard, P, Helweg-Larsen, J, Faurholt-Jepsen, D, Østergaard, L, Køber, L & Fosbøl, EL 2024, 'NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry', American Heart Journal, vol. 268, pp. 80-93. https://doi.org/10.1016/j.ahj.2023.11.018

TY - JOUR

T1 - NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry

AU - Graversen, Peter L.

AU - Hadji-Turdeghal, Katra

AU - Møller, Jacob Eifer

AU - Bruun, Niels Eske

AU - Laghmoch, Hicham

AU - Jensen, Andreas Dalsgaard

AU - Petersen, Jeppe K.

AU - Bundgaard, Henning

AU - Iversen, Kasper

AU - Povlsen, Jonas A.

AU - Moser, Claus

AU - Smerup, Morten

AU - Jensen, Hanne Sortsøe

AU - Søgaard, Peter

AU - Helweg-Larsen, Jannik

AU - Faurholt-Jepsen, Daniel

AU - Østergaard, Lauge

AU - Køber, Lars

AU - Fosbøl, Emil L.

PY - 2024/2

Y1 - 2024/2

N2 - AIMS: The NatIonal Danish endocarditis stUdieS (NIDUS) registry aims to investigate the mechanisms contributing to the increasing incidence of infective endocarditis (IE) and to discover risk factors associated to the course, treatment and clinical outcomes of the disease.METHODS: The NIDUS registry was created to investigate a nationwide unselected group of patients hospitalized for IE. The National Danish healthcare registries have been queried for validated IE diagnosis codes (International Classification of Disease, 10th edition [ICD-10]: DI33, DI38, and DI398). Subsequently, a team of 28 healthcare professionals, including experts in endocarditis, will systematically review and evaluate all identified patient records using the modified Duke Criteria and the 2015 European Society of Cardiology modified diagnostic criteria. The registry will contain all cases with definite or possible IE found in primary data sources in Denmark between January 1, 2016, and December 31, 2021. We will gather individual patient data, such as clinical, microbiological, and echocardiographic characteristics, treatment regimens, and clinical outcomes. A digital data collection form will be used to the gathering of data. A sample of approximately 4,300 individual patients will be evaluated using primary data sources.CONCLUSIONS AND PERSPECTIVES: The NIDUS registry will be the first comprehensive nationwide IE registry, contributing critical knowledge about the course, treatment, and clinical outcomes of the disease. Additionally, it will significantly aid in identifying areas in which future research is needed.

AB - AIMS: The NatIonal Danish endocarditis stUdieS (NIDUS) registry aims to investigate the mechanisms contributing to the increasing incidence of infective endocarditis (IE) and to discover risk factors associated to the course, treatment and clinical outcomes of the disease.METHODS: The NIDUS registry was created to investigate a nationwide unselected group of patients hospitalized for IE. The National Danish healthcare registries have been queried for validated IE diagnosis codes (International Classification of Disease, 10th edition [ICD-10]: DI33, DI38, and DI398). Subsequently, a team of 28 healthcare professionals, including experts in endocarditis, will systematically review and evaluate all identified patient records using the modified Duke Criteria and the 2015 European Society of Cardiology modified diagnostic criteria. The registry will contain all cases with definite or possible IE found in primary data sources in Denmark between January 1, 2016, and December 31, 2021. We will gather individual patient data, such as clinical, microbiological, and echocardiographic characteristics, treatment regimens, and clinical outcomes. A digital data collection form will be used to the gathering of data. A sample of approximately 4,300 individual patients will be evaluated using primary data sources.CONCLUSIONS AND PERSPECTIVES: The NIDUS registry will be the first comprehensive nationwide IE registry, contributing critical knowledge about the course, treatment, and clinical outcomes of the disease. Additionally, it will significantly aid in identifying areas in which future research is needed.

KW - Denmark/epidemiology

KW - Echocardiography

KW - Endocarditis, Bacterial/diagnosis

KW - Endocarditis/diagnosis

KW - Humans

KW - Registries

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U2 - 10.1016/j.ahj.2023.11.018

DO - 10.1016/j.ahj.2023.11.018

M3 - Journal article

C2 - 38056547

SN - 0002-8703

VL - 268

SP - 80

EP - 93

JO - American Heart Journal

JF - American Heart Journal

ER -

NatIonal Danish endocarditis stUdieS - Design and objectives of the NIDUS registry

Abstract

Bibliographical note

Keywords

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AUB Link

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