Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated 68Ga PSMA and 99mTc HDP Uptake with No Signs of Malignancy

Morten Bentestuen; Maria Carlsen Elkjær; Helle D. Zacho

doi:10.1055/s-0042-1758805

Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated ⁶⁸Ga PSMA and ^99mTc HDP Uptake with No Signs of Malignancy

Morten Bentestuen^*, Maria Carlsen Elkjær, Helle D. Zacho

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( 68 Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, 68 Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, 68 Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.

Original language	English
Journal	World Journal of Nuclear Medicine
Volume	22
Issue number	1
Pages (from-to)	67-69
Number of pages	3
ISSN	1450-1147
DOIs	https://doi.org/10.1055/s-0042-1758805
Publication status	Published - Sept 2023

Bibliographical note

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).

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10.1055/s-0042-1758805Licence: CC BY 4.0

Bentestuen, Elkjær & Zacho (2023). Not All Glittering Bone Lesions Are Gold - A Case of Sclerotic Bone Lesions with Elevated 68 Ga PSMA and 99m Tc HDP Uptake with No Signs of MalignancyFinal published version, 1.95 MBLicence: CC BY 4.0

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title = "Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated 68Ga PSMA and 99mTc HDP Uptake with No Signs of Malignancy",

abstract = "Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( 68 Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, 68 Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, 68 Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.",

author = "Morten Bentestuen and Elkj{\ae}r, {Maria Carlsen} and Zacho, {Helle D.}",

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Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated ⁶⁸Ga PSMA and ^99mTc HDP Uptake with No Signs of Malignancy. / Bentestuen, Morten; Elkjær, Maria Carlsen; Zacho, Helle D.
In: World Journal of Nuclear Medicine, Vol. 22, No. 1, 09.2023, p. 67-69.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Elkjær, Maria Carlsen

AU - Zacho, Helle D.

N1 - The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).

PY - 2023/9

Y1 - 2023/9

N2 - Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( 68 Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, 68 Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, 68 Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.

AB - Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( 68 Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, 68 Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, 68 Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.

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