Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

Camilla Ståhl; Richard Upton; David J.R. Foster; Lona Louring Christrup; Kim Kristensen; Steen Honoré Hansen; Lars Arendt-Nielsen; Asbjørn Mohr Drewes

doi:10.1177/0091270008314465

Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

Camilla Ståhl, Richard Upton, David J.R. Foster, Lona Louring Christrup, Kim Kristensen, Steen Honoré Hansen, Lars Arendt-Nielsen, Asbjørn Mohr Drewes

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

Abstract

Udgivelsesdato: MAY

Original language	English
Journal	The Journal of Clinical Pharmacology
Volume	48
Issue number	5
Pages (from-to)	619-631
Number of pages	12
ISSN	0091-2700
DOIs	https://doi.org/10.1177/0091270008314465
Publication status	Published - 2008

Keywords

Administration, Oral
Adult
Algorithms
Analgesics, Opioid
Area Under Curve
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Electric Stimulation
Female
Hot Temperature
Humans
Infusions, Parenteral
Male
Models, Biological
Morphine
Oxycodone
Pain
Pain Measurement
Pain Threshold
Physical Stimulation

Access to Document

10.1177/0091270008314465

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Cite this

Ståhl, C., Upton, R., Foster, D. J. R., Christrup, L. L., Kristensen, K., Hansen, S. H., Arendt-Nielsen, L., & Drewes, A. M. (2008). Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model. The Journal of Clinical Pharmacology, 48(5), 619-631. https://doi.org/10.1177/0091270008314465

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keywords = "Administration, Oral, Adult, Algorithms, Analgesics, Opioid, Area Under Curve, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Electric Stimulation, Female, Hot Temperature, Humans, Infusions, Parenteral, Male, Models, Biological, Morphine, Oxycodone, Pain, Pain Measurement, Pain Threshold, Physical Stimulation",

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AU - Ståhl, Camilla

AU - Upton, Richard

AU - Foster, David J.R.

AU - Christrup, Lona Louring

AU - Kristensen, Kim

AU - Hansen, Steen Honoré

AU - Arendt-Nielsen, Lars

AU - Drewes, Asbjørn Mohr

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KW - Area Under Curve

KW - Cross-Over Studies

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Electric Stimulation

KW - Female

KW - Hot Temperature

KW - Humans

KW - Infusions, Parenteral

KW - Male

KW - Models, Biological

KW - Morphine

KW - Oxycodone

KW - Pain

KW - Pain Measurement

KW - Pain Threshold

KW - Physical Stimulation

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