Platformsforsøg

Anders Perner; Maj-Brit N. Kjær; Hans-Christian Thorsen-Meyer; Benjamin S. Kaas-Hansen; Marie W. Munch; Marie O. Collet; Camilla R. L. Bruun; Aksel K. G. Jensen; Theis Lange; Trine Albertsen; Claus Duedal Pedersen; Lone M. Poulsen; Ole Mathiesen; Anne C. Brøchner; Thomas Strøm; Lars W. Andersen; Steffen Christensen; Bodil S. Rasmussen; Olav L. Schjørring; Mathias Maagaard; Morten Hylander Møller; Anders Granholm

Platformsforsøg

Translated title of the contribution: Platform trials

Anders Perner^*, Maj-Brit N. Kjær, Hans-Christian Thorsen-Meyer, Benjamin S. Kaas-Hansen, Marie W. Munch, Marie O. Collet, Camilla R. L. Bruun, Aksel K. G. Jensen, Theis Lange, Trine Albertsen, Claus Duedal Pedersen, Lone M. Poulsen, Ole Mathiesen, Anne C. Brøchner, Thomas Strøm, Lars W. Andersen, Steffen Christensen, Bodil S. Rasmussen, Olav L. Schjørring, Mathias MaagaardMorten Hylander Møller, Anders Granholm

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

Translated title of the contribution	Platform trials
Original language	Danish
Article number	V04230237
Journal	Ugeskrift for Læger
Volume	185
ISSN	0041-5782
Publication status	Published - 9 Oct 2023

Bibliographical note

Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

Access to Document

Perner et al. (2023). PlatformsforsøgFinal published version, 816 KBLicence: CC BY-NC-ND 4.0

https://ugeskriftet.dk/videnskab/platformsforsogLicence: CC BY-NC-ND 4.0

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Perner, A., Kjær, M.-B. N., Thorsen-Meyer, H.-C., Kaas-Hansen, B. S., Munch, M. W., Collet, M. O., Bruun, C. R. L., Jensen, A. K. G., Lange, T., Albertsen, T., Pedersen, C. D., Poulsen, L. M., Mathiesen, O., Brøchner, A. C., Strøm, T., Andersen, L. W., Christensen, S., Rasmussen, B. S., Schjørring, O. L., ... Granholm, A. (2023). Platformsforsøg. Ugeskrift for Læger, 185, Article V04230237. https://ugeskriftet.dk/videnskab/platformsforsog

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title = "Platformsfors{\o}g",

abstract = "Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.",

keywords = "COVID-19/epidemiology, Humans, Pandemics",

author = "Anders Perner and Kj{\ae}r, {Maj-Brit N.} and Hans-Christian Thorsen-Meyer and Kaas-Hansen, {Benjamin S.} and Munch, {Marie W.} and Collet, {Marie O.} and Bruun, {Camilla R. L.} and Jensen, {Aksel K. G.} and Theis Lange and Trine Albertsen and Pedersen, {Claus Duedal} and Poulsen, {Lone M.} and Ole Mathiesen and Br{\o}chner, {Anne C.} and Thomas Str{\o}m and Andersen, {Lars W.} and Steffen Christensen and Rasmussen, {Bodil S.} and Schj{\o}rring, {Olav L.} and Mathias Maagaard and M{\o}ller, {Morten Hylander} and Anders Granholm",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2023",

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Perner, A, Kjær, M-BN, Thorsen-Meyer, H-C, Kaas-Hansen, BS, Munch, MW, Collet, MO, Bruun, CRL, Jensen, AKG, Lange, T, Albertsen, T, Pedersen, CD, Poulsen, LM, Mathiesen, O, Brøchner, AC, Strøm, T, Andersen, LW, Christensen, S, Rasmussen, BS , Schjørring, OL, Maagaard, M, Møller, MH & Granholm, A 2023, 'Platformsforsøg', Ugeskrift for Læger, vol. 185, V04230237. <https://ugeskriftet.dk/videnskab/platformsforsog>

TY - JOUR

T1 - Platformsforsøg

AU - Perner, Anders

AU - Kjær, Maj-Brit N.

AU - Thorsen-Meyer, Hans-Christian

AU - Kaas-Hansen, Benjamin S.

AU - Munch, Marie W.

AU - Collet, Marie O.

AU - Bruun, Camilla R. L.

AU - Jensen, Aksel K. G.

AU - Lange, Theis

AU - Albertsen, Trine

AU - Pedersen, Claus Duedal

AU - Poulsen, Lone M.

AU - Mathiesen, Ole

AU - Brøchner, Anne C.

AU - Strøm, Thomas

AU - Andersen, Lars W.

AU - Christensen, Steffen

AU - Rasmussen, Bodil S.

AU - Schjørring, Olav L.

AU - Maagaard, Mathias

AU - Møller, Morten Hylander

AU - Granholm, Anders

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2023/10/9

Y1 - 2023/10/9

N2 - Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

AB - Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

KW - COVID-19/epidemiology

KW - Humans

KW - Pandemics

M3 - Tidsskriftartikel

C2 - 37873986

SN - 0041-5782

VL - 185

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

M1 - V04230237

ER -

Platformsforsøg

Abstract

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