Precise MRI-based stereotaxic surgery in large animal models

A. N. Glud; J. Bech; L. Tvilling; H. Zaer; D. Orlowski; L. M. Fitting; D. Ziedler; M. Geneser; R. Sangill; A. K. O. Alstrup; C. R. Bjarkam; J. Sorensen

Abstract

BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.

NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.

RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.

COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.

CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

Original language	English
Publication date	2017
Publication status	Published - 2017
Event	47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017 - Washington, DC, United States Duration: 11 Nov 2017 → 15 Nov 2017

Conference

Conference	47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017
Country/Territory	United States
City	Washington, DC
Period	11/11/2017 → 15/11/2017

Keywords

Journal Article

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http://www.abstractsonline.com/pp8/#!/4376/presentation/32821

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Cite this

Glud, A. N., Bech, J., Tvilling, L., Zaer, H., Orlowski, D., Fitting, L. M., Ziedler, D., Geneser, M., Sangill, R., Alstrup, A. K. O., Bjarkam, C. R., & Sorensen, J. (2017). Precise MRI-based stereotaxic surgery in large animal models. Abstract from 47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017, Washington, DC, United States. http://www.abstractsonline.com/pp8/#!/4376/presentation/32821

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title = "Precise MRI-based stereotaxic surgery in large animal models",

abstract = "BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MR{\'I}s. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.",

keywords = "Journal Article",

author = "Glud, {A. N.} and J. Bech and L. Tvilling and H. Zaer and D. Orlowski and Fitting, {L. M.} and D. Ziedler and M. Geneser and R. Sangill and Alstrup, {A. K. O.} and Bjarkam, {C. R.} and J. Sorensen",

note = "Abstract 389.16 / Y16; 47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017 ; Conference date: 11-11-2017 Through 15-11-2017",

year = "2017",

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Glud, AN, Bech, J, Tvilling, L, Zaer, H, Orlowski, D, Fitting, LM, Ziedler, D, Geneser, M, Sangill, R, Alstrup, AKO, Bjarkam, CR & Sorensen, J 2017, 'Precise MRI-based stereotaxic surgery in large animal models', 47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017, Washington, DC, United States, 11/11/2017 - 15/11/2017. <http://www.abstractsonline.com/pp8/#!/4376/presentation/32821>

TY - ABST

T1 - Precise MRI-based stereotaxic surgery in large animal models

AU - Glud, A. N.

AU - Bech, J.

AU - Tvilling, L.

AU - Zaer, H.

AU - Orlowski, D.

AU - Fitting, L. M.

AU - Ziedler, D.

AU - Geneser, M.

AU - Sangill, R.

AU - Alstrup, A. K. O.

AU - Bjarkam, C. R.

AU - Sorensen, J.

N1 - Abstract 389.16 / Y16

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

AB - BACKGROUND: Stereotaxic neurosurgery in large animals is used widely in different sophisticated models, where precision is becoming more crucial as desired anatomical target regions are becoming smaller. Individually calculated coordinates are necessary in large animal models with cortical and subcortical anatomical differences.NEW METHOD: We present a convenient method to make an MRI-visible skull fiducial for 3D MRI-based stereotaxic procedures in larger experimental animals. Plastic screws were filled with either copper-sulphate solution or MRI-visible paste from a commercially available cranial head marker. The screw fiducials were inserted in the animal skulls and T1 weighted MRI was performed allowing identification of the inserted skull marker.RESULTS: Both types of fiducial markers were clearly visible on the MRÍs. This allows high precision in the stereotaxic space.COMPARISON WITH EXISTING METHOD: The use of skull bone based fiducial markers gives high precision for both targeting and evaluation of stereotaxic systems. There are no metal artifacts and the fiducial is easily removed after surgery.CONCLUSION: The fiducial marker can be used as a very precise reference point, either for direct targeting or in evaluation of other stereotaxic systems.

KW - Journal Article

M3 - Conference abstract for conference

T2 - 47th Annual Meeting of the Society for Neuroscience, Neuroscience 2017

Y2 - 11 November 2017 through 15 November 2017

ER -