Single Nucleotide Polymorphisms in IL1B and the Risk of Acute Coronary Syndrome: A Danish Case-Cohort Study

Jakob Gerhard Stegger; Erik Berg Schmidt; Anne Tjønneland; Tine Iskov Kopp; Thorkild Sørensen; Ulla Vogel; Kim Overvad

doi:10.1371/journal.pone.0036829

Single Nucleotide Polymorphisms in IL1B and the Risk of Acute Coronary Syndrome: A Danish Case-Cohort Study

Jakob Gerhard Stegger, Erik Berg Schmidt, Anne Tjønneland, Tine Iskov Kopp, Thorkild Sørensen, Ulla Vogel, Kim Overvad

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

Original language	English
Volume	7
Pages (from-to)	e36829
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0036829
Publication status	Published - 2012
Externally published	Yes

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title = "Single Nucleotide Polymorphisms in IL1B and the Risk of Acute Coronary Syndrome: A Danish Case-Cohort Study",

abstract = "Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.",

author = "Stegger, {Jakob Gerhard} and Schmidt, {Erik Berg} and Anne Tj{\o}nneland and Kopp, {Tine Iskov} and Thorkild S{\o}rensen and Ulla Vogel and Kim Overvad",

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T1 - Single Nucleotide Polymorphisms in IL1B and the Risk of Acute Coronary Syndrome

T2 - A Danish Case-Cohort Study

AU - Stegger, Jakob Gerhard

AU - Schmidt, Erik Berg

AU - Tjønneland, Anne

AU - Kopp, Tine Iskov

AU - Sørensen, Thorkild

AU - Vogel, Ulla

AU - Overvad, Kim

PY - 2012

Y1 - 2012

N2 - Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

AB - Interleukin-1B (IL-1B) is a key pro-inflammatory cytokine that has been associated with the development of atherosclerosis and myocardial infarction. However, the prospective associations between functional single nucleotide polymorphisms (SNPs) in IL1B and incident acute coronary syndrome (ACS) have not been thoroughly investigated. The aims of this study were to examine the associations between individual SNPs in and SNP haplotypes of the promoter region of IL1B and incident ACS in a prospective study. Furthermore, we wanted to explore potential interactions with other risk factors for ACS on an additive scale.

U2 - 10.1371/journal.pone.0036829

DO - 10.1371/journal.pone.0036829

M3 - Journal article

SN - 1932-6203

VL - 7

SP - e36829

ER -

Single Nucleotide Polymorphisms in IL1B and the Risk of Acute Coronary Syndrome: A Danish Case-Cohort Study

Abstract

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