TY - JOUR
T1 - The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes
AU - Nabrdalik-Leśniak, Diana
AU - Nabrdalik, Katarzyna
AU - Irlik, Krzysztof
AU - Janota, Oliwia
AU - Kwiendacz, Hanna
AU - Szromek-Białek, Paulina
AU - Maziarz, Mirosław
AU - Stompór, Tomasz
AU - Gumprecht, Janusz
AU - Lip, Gregory Y. H.
PY - 2023
Y1 - 2023
N2 - There is increasing interest in sodium-glucose cotransporter 2 inhibitors (SGLT2i) as not only a new oral glucose-lowering drug class but also one with cardio- and nephroprotective potential. Understanding the underlying mechanisms is therefore of great interest, and postulated benefits have included increased natriuresis, lower blood pressure, increased haematocrit, enhanced cardiac fatty acid utilization, reduced low-grade inflammation, and decreased oxidative stress. In particular, redox homeostasis seems to be crucial in the pathogenesis of heart and kidney disease in diabetes, and there is accumulating evidence that SGLT2i have beneficial effects in this perspective. In this review, we aimed to summarize the potential mechanisms of the influence of SGLT2i on oxidative stress parameters in animal and human studies, with a special focus on heart failure and chronic kidney disease in diabetes mellitus.
AB - There is increasing interest in sodium-glucose cotransporter 2 inhibitors (SGLT2i) as not only a new oral glucose-lowering drug class but also one with cardio- and nephroprotective potential. Understanding the underlying mechanisms is therefore of great interest, and postulated benefits have included increased natriuresis, lower blood pressure, increased haematocrit, enhanced cardiac fatty acid utilization, reduced low-grade inflammation, and decreased oxidative stress. In particular, redox homeostasis seems to be crucial in the pathogenesis of heart and kidney disease in diabetes, and there is accumulating evidence that SGLT2i have beneficial effects in this perspective. In this review, we aimed to summarize the potential mechanisms of the influence of SGLT2i on oxidative stress parameters in animal and human studies, with a special focus on heart failure and chronic kidney disease in diabetes mellitus.
KW - chronic kidney disease
KW - diabetes mellitus
KW - heart failure
KW - oxidative stress
KW - sodium-glucose cotransporter 2 inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85176548893&partnerID=8YFLogxK
U2 - 10.5603/EP.a2023.0039
DO - 10.5603/EP.a2023.0039
M3 - Review article
C2 - 37431873
SN - 0423-104X
VL - 74
SP - 349
EP - 362
JO - Endokrynologia Polska
JF - Endokrynologia Polska
IS - 4
ER -