The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Daniele Campa; Anika Husing; James D McKay; Olga Sinilnikova; Ulla Vogel; Anne Tjonneland; Kim Overvad; Jakob Stegger; Francoise Clavel-Chapelon; Nathalie Chabbert-Buffet; Guy Fagherazzi; Antonia Trichopoulou; Dimosthenis Zylis; Erifili Oustoglou; Sabine Rohrmann; Birgit Teucher; Eva Fisher; Heiner Boeing; Giovanna Masala; Vittorio Krogh; Carlotta Sacerdote; Salvatore Panico; Rosario Tumino; N Charlotte Onland-Moret; Carla H van Gils; H Bas Bueno-de-Mesquita; Eiliv Lund; Maria Dolores Chirlaque; Nuria Sala; Jose Ramon Quiros; Eva Ardanaz; Pilar Amiano; Esther Molina-Montes; Goran Hallmans; Per Lenner; Ruth C Travis; Timothy J Key; Nicholas Wareham; Kay-Tee Khaw; Sabina Rinaldi; Nadia Slimani; Veronique Chajes; Afshan Siddiq; Elio Riboli; Rudolf Kaaks; Federico Canzian

doi:10.1186/1471-2407-10-563

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Daniele Campa, Anika Husing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjonneland, Kim Overvad, Jakob Stegger, Francoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher, Eva Fisher, Heiner Boeing, Giovanna Masala, Vittorio KroghCarlotta Sacerdote, Salvatore Panico, Rosario Tumino, N Charlotte Onland-Moret, Carla H van Gils, H Bas Bueno-de-Mesquita, Eiliv Lund, Maria Dolores Chirlaque, Nuria Sala, Jose Ramon Quiros, Eva Ardanaz, Pilar Amiano, Esther Molina-Montes, Goran Hallmans, Per Lenner, Ruth C Travis, Timothy J Key, Nicholas Wareham, Kay-Tee Khaw, Sabina Rinaldi, Nadia Slimani, Veronique Chajes, Afshan Siddiq, Elio Riboli, Rudolf Kaaks, Federico Canzian

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Abstract

ABSTRACT: BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). METHODS: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

Original language	English
Journal	B M C Cancer
Volume	10
Pages (from-to)	563
ISSN	1471-2407
DOIs	https://doi.org/10.1186/1471-2407-10-563
Publication status	Published - 2010
Externally published	Yes

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Campa, D., Husing, A., McKay, J. D., Sinilnikova, O., Vogel, U., Tjonneland, A., Overvad, K., Stegger, J., Clavel-Chapelon, F., Chabbert-Buffet, N., Fagherazzi, G., Trichopoulou, A., Zylis, D., Oustoglou, E., Rohrmann, S., Teucher, B., Fisher, E., Boeing, H., Masala, G., ... Canzian, F. (2010). The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. B M C Cancer, 10, 563. https://doi.org/10.1186/1471-2407-10-563

@article{ca3359829931488d84626ab2b4805930,

title = "The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk",

abstract = "ABSTRACT: BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). METHODS: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.",

author = "Daniele Campa and Anika Husing and McKay, {James D} and Olga Sinilnikova and Ulla Vogel and Anne Tjonneland and Kim Overvad and Jakob Stegger and Francoise Clavel-Chapelon and Nathalie Chabbert-Buffet and Guy Fagherazzi and Antonia Trichopoulou and Dimosthenis Zylis and Erifili Oustoglou and Sabine Rohrmann and Birgit Teucher and Eva Fisher and Heiner Boeing and Giovanna Masala and Vittorio Krogh and Carlotta Sacerdote and Salvatore Panico and Rosario Tumino and Onland-Moret, {N Charlotte} and {van Gils}, {Carla H} and Bueno-de-Mesquita, {H Bas} and Eiliv Lund and Chirlaque, {Maria Dolores} and Nuria Sala and Quiros, {Jose Ramon} and Eva Ardanaz and Pilar Amiano and Esther Molina-Montes and Goran Hallmans and Per Lenner and Travis, {Ruth C} and Key, {Timothy J} and Nicholas Wareham and Kay-Tee Khaw and Sabina Rinaldi and Nadia Slimani and Veronique Chajes and Afshan Siddiq and Elio Riboli and Rudolf Kaaks and Federico Canzian",

year = "2010",

doi = "10.1186/1471-2407-10-563",

language = "English",

volume = "10",

pages = "563",

journal = "B M C Cancer",

issn = "1471-2407",

publisher = "BioMed Central",

}

Campa, D, Husing, A, McKay, JD, Sinilnikova, O, Vogel, U, Tjonneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, NC, van Gils, CH, Bueno-de-Mesquita, HB, Lund, E, Chirlaque, MD, Sala, N, Quiros, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, RC, Key, TJ, Wareham, N, Khaw, K-T, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R & Canzian, F 2010, 'The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk', B M C Cancer, vol. 10, pp. 563. https://doi.org/10.1186/1471-2407-10-563

TY - JOUR

T1 - The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

AU - Campa, Daniele

AU - Husing, Anika

AU - McKay, James D

AU - Sinilnikova, Olga

AU - Vogel, Ulla

AU - Tjonneland, Anne

AU - Overvad, Kim

AU - Stegger, Jakob

AU - Clavel-Chapelon, Francoise

AU - Chabbert-Buffet, Nathalie

AU - Fagherazzi, Guy

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Oustoglou, Erifili

AU - Rohrmann, Sabine

AU - Teucher, Birgit

AU - Fisher, Eva

AU - Boeing, Heiner

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Sacerdote, Carlotta

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Onland-Moret, N Charlotte

AU - van Gils, Carla H

AU - Bueno-de-Mesquita, H Bas

AU - Lund, Eiliv

AU - Chirlaque, Maria Dolores

AU - Sala, Nuria

AU - Quiros, Jose Ramon

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Molina-Montes, Esther

AU - Hallmans, Goran

AU - Lenner, Per

AU - Travis, Ruth C

AU - Key, Timothy J

AU - Wareham, Nicholas

AU - Khaw, Kay-Tee

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Chajes, Veronique

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Kaaks, Rudolf

AU - Canzian, Federico

PY - 2010

Y1 - 2010

N2 - ABSTRACT: BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). METHODS: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

AB - ABSTRACT: BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). METHODS: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

U2 - 10.1186/1471-2407-10-563

DO - 10.1186/1471-2407-10-563

M3 - Journal article

SN - 1471-2407

VL - 10

SP - 563

JO - B M C Cancer

JF - B M C Cancer

ER -

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

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