Abstract
PURPOSE OF REVIEW: To discuss the spectrum of diabetes related to acute and chronic pancreatitis (which are types of pancreatogenic diabetes) and its overlapping features with type 1 and type 2 diabetes.
RECENT FINDINGS: Patients with diabetes related to acute and chronic pancreatitis present clinically within a spectrum of overlapping features with other forms of diabetes. In this spectrum, glucose metabolism alterations range from increased insulin resistance following acute pancreatitis (resembling type 2 diabetes) towards a permanent loss of beta-cell function and impaired insulin secretion in end-stage chronic pancreatitis. Overlapping features with type 1 diabetes (beta cell autoantibodies) and type 2 diabetes (obesity, dyslipidemia, and hereditary/genetic factors) contribute to the heterogeneity of this spectrum.
SUMMARY: Pancreatogenic diabetes secondary to acute or chronic pancreatitis is a heterogeneous entity with a variable clinical presentation, including many cases that are misdiagnosed and treated as type 2 diabetes. This is problematic as pancreatogenic diabetes is associated with a poor prognosis and entails special considerations for management. Recent discoveries showing overlapping features with type 1 and type 2 diabetes along with an improved understanding of its pathophysiology are expected to improve the diagnosis and treatment of these and other forms of pancreatogenic diabetes.
Original language | English |
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Journal | Current opinion in gastroenterology |
Volume | 38 |
Issue number | 5 |
Pages (from-to) | 509-515 |
Number of pages | 7 |
ISSN | 0267-1379 |
DOIs | |
Publication status | Published - 1 Sept 2022 |
Bibliographical note
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.Keywords
- Acute Disease
- Diabetes Mellitus
- Diabetes Mellitus, Type 1/complications
- Diabetes Mellitus, Type 2/complications
- Humans
- Pancreatitis, Chronic/complications
- type 1 diabetes
- type 3c diabetes
- type 2 diabetes
- pancreatogenic diabetes
- mechanisms