Aktiviteter pr. år
Projektdetaljer
Beskrivelse
-Development of the innate immune system in the newborn.
-Neutrophil granulocytes and neutrophil extracellular traps in inflammatory diseases, including inflammatory bowel disease.
-Role of complement system in sepsis.
-Neutrophil granulocytes and neutrophil extracellular traps in inflammatory diseases, including inflammatory bowel disease.
-Role of complement system in sepsis.
Nøgleresultater
-Immune system develops consistently only hours after birth.
-The classical complement activation pathway and membrane attach complex (MAC, or terminal complement complex TCC) are prioritized and may be central for newborn immune protection to pathogens.
-Neutrophil extracellular traps are invovled in the ulcerative colitis (UC) inflammatory bowel disease (IBD) etiology.
-Sepsis may be connected to evading complement system activation.
-The classical complement activation pathway and membrane attach complex (MAC, or terminal complement complex TCC) are prioritized and may be central for newborn immune protection to pathogens.
-Neutrophil extracellular traps are invovled in the ulcerative colitis (UC) inflammatory bowel disease (IBD) etiology.
-Sepsis may be connected to evading complement system activation.
| Status | Igangværende |
|---|---|
| Effektiv start/slut dato | 01/01/2014 → … |
Finansiering
- Carlsbergfondet: 350.000,00 kr.
- Lundbeckfonden: 700.000,00 kr.
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal: 50.000,00 kr.
Fingerprint
Udforsk forskningsemnerne, som dette projekt berører. Disse etiketter er oprettet på grundlag af de underliggende bevillinger/legater. Sammen danner de et unikt fingerprint.
Aktiviteter
- 2 Konferenceoplæg
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Large scale proteomics of biofluids
Tue Bjerg Bennike (Foredragsholder)
5 dec. 2023Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
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Autoimmune diseases and breach of immune tolerance
Tue Bjerg Bennike (Foredragsholder)
3 feb. 2022Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
Publikation
-
Molecular insights into patent ductus arteriosus in extremely preterm neonates: More than a hemodynamic challenge
Bennike, T. B., Sellmer, A., Henriksen, T. B., Palmfeldt, J., Bech, B. H., Astono, J. & Hjortdal, V. E., 6 dec. 2022.Publikation: Konferencebidrag uden forlag/tidsskrift › Poster › Forskning
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New insights into the ulcerative colitis etiology from multi-OMICS integration analysis of the colon mucosa proteome and transcriptome
Bennike, T. B., Christiansen, G., Birkelund, S. & Andersen, V., 29 aug. 2022.Publikation: Konferencebidrag uden forlag/tidsskrift › Poster › Forskning › peer review
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Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy with Islet Autotransplantation
Bennike, T. B., Templeton, K., Fujimura, K., Bellin, M. D., Ahmed, S., Schlaffner, C. N., Arora, R., Cruz-Monserrate, Z., Arnaout, R., Beilman, G. J., Groverc, A. S., Conwell, D. L. & Steen, H., maj 2022, I: Pancreas. 51, 5, s. 435-444 10 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgang1 Citationer (Scopus)
Presse/medier
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How Do Our Immune Systems Develop in the First Days of Life?
22/10/2020
6 elementer af Mediedækning
Presse/medie
-
Bedre børnevaccination med Big Data: Ny forskning kortlægger nyfødtes komplicerede første uge
14/03/2019 → 14/03/2019
4 elementer af Mediedækning
Presse/medie
-
Small babies, big data - Systems biology reveals babies' detailed developmental trajectory during week 1 of life
12/03/2019
1 element af Mediedækning
Presse/medie
Forskningsdatasæt
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Complement deposition on Chlamydia trachomatis
Bennike, T. B. (Ophavsperson), Nielsen, M. L. (Ophavsperson), Thomsen, M. E. (Ophavsperson), Christiansen, G. (Ophavsperson), Karred, N. (Ophavsperson), Stensballe, A. (Ophavsperson) & Birkelund, S. (Ophavsperson), PRoteomics IDEntifications Database (PRIDE), 26 maj 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD019393
Datasæt
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Depleted Prefractionated Human Plasma for Data Independent Acquisition Spectral Library
Bennike, T. B. (Ophavsperson), Bellin, M. D. (Bidrager), Xuan, Y. (Bidrager), Stensballe, A. (Bidrager), Møller, F. T. (Bidrager), Beilman, G. (Bidrager), Levy, O. (Bidrager), Cruz-Monserrate, Z. (Bidrager), Andersen, V. (Bidrager), Steen, J. (Bidrager), Conwell, D. L. (Bidrager) & Steen, H. (Bidrager), PRoteomics IDEntifications Database (PRIDE), 18 apr. 2018
https://www.ebi.ac.uk/pride/archive/projects/PXD008163
Datasæt
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A proteome analysis by LC-MS/MS of human colon mucosal biopsies from gastrointestinal healthy rheumatoid arthritis patients
Bennike, T. B. (Ophavsperson), Ellingsen, T. (Bidrager), Glerup, H. (Bidrager), Bonderup, O. K. (Bidrager), Carlsen, T. G. (Bidrager), Meyer, M. K. (Bidrager), Bøgsted, M. (Bidrager), Christiansen, G. (Bidrager), Birkelund, S. (Bidrager), Andersen, V. (Bidrager) & Stensballe, A. (Ophavsperson), PRoteomics IDEntifications Database (PRIDE), 26 sep. 2016
https://www.ebi.ac.uk/pride/archive/projects/PXD003082
Datasæt