Abstract
BACKGROUND: The Predict Recovery Potential algorithm (PREP2) was developed to predict upper limb (UL) function early after stroke. However, assessment in the acute phase is not always possible.
OBJECTIVE: To assess the prognostic accuracy of the PREP2 when applied in a subacute neurorehabilitation setting.
METHODS: This prospective longitudinal study included patients ≥18 years old with UL impairment following stroke. Patients were assessed in accordance with the PREP2 approach. However, 2 main components, the shoulder abduction finger extension (SAFE) score and motor-evoked potentials (MEPs) were obtained 2 weeks poststroke. UL function at 3 months was predicted in 1 of 4 categories and compared with the actual outcome at 3 months as assessed by the Action Research Arm Test. The prediction accuracy of the PREP2 was quantified using the correct classification rate (CCR).
RESULTS: Ninety-one patients were included. Overall CCR of the PREP2 was 60% (95% CI 50%-71%). Within the 4 categories, CCR ranged from the lowest value at 33% (95% CI 4%-85%) for the category Limited to the highest value at 78% (95% CI 43%-95%) for the category Poor. In the present study, the overall CCR was significantly lower (P < .001) than the 75% reported by the PREP2 developers.
CONCLUSIONS: The low overall CCR makes PREP2 obtained 2 weeks poststroke unsuited for clinical implementation. However, PREP2 may be used to predict either excellent UL function in already well-recovered patients or poor UL function in patients with persistent severe UL paresis.
Originalsprog | Engelsk |
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Tidsskrift | Neurorehabilitation and Neural Repair |
Vol/bind | 35 |
Udgave nummer | 1 |
Sider (fra-til) | 68-78 |
Antal sider | 11 |
ISSN | 1545-9683 |
DOI | |
Status | Udgivet - jan. 2021 |
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Accuracy of the Upper Limb Prediction Algorithm PREP2 Applied 2 Weeks Poststroke: A Prospective Longitudinal Study
Lundquist, C. B. (Ophavsperson), Nielsen, J. F. (Ophavsperson), Arguissain, F. G. (Ophavsperson) & Brunner, I. C. (Ophavsperson), Sage Journals, 2020
DOI: 10.25384/sage.c.5215078, https://sage.figshare.com/collections/Accuracy_of_the_Upper_Limb_Prediction_Algorithm_PREP2_Applied_2_Weeks_Poststroke_A_Prospective_Longitudinal_Study/5215078
Datasæt
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Accuracy of the Upper Limb Prediction Algorithm PREP2 Applied 2 Weeks Poststroke: A Prospective Longitudinal Study
Lundquist, C. B. (Ophavsperson), Nielsen, J. F. (Ophavsperson), Arguissain, F. G. (Ophavsperson) & Brunner, I. C. (Ophavsperson), Sage Journals, 2020
DOI: 10.25384/sage.c.5215078.v1, https://sage.figshare.com/collections/Accuracy_of_the_Upper_Limb_Prediction_Algorithm_PREP2_Applied_2_Weeks_Poststroke_A_Prospective_Longitudinal_Study/5215078/1
Datasæt
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sj-pdf-1-nnr-10.1177_1545968320971763 – Supplemental material for Accuracy of the Upper Limb Prediction Algorithm PREP2 Applied 2 Weeks Poststroke: A Prospective Longitudinal Study
Lundquist, C. B. (Ophavsperson), Nielsen, J. F. (Ophavsperson), Arguissain, F. G. (Ophavsperson) & Brunner, I. C. (Ophavsperson), Sage Journals, 2020
DOI: 10.25384/sage.13270666.v1, https://doi.org/10.25384%2Fsage.13270666.v1
Datasæt: Supplerende materiale