TY - JOUR
T1 - Chronic neuropathic pain is more than a perception
T2 - systems and methods for an integral characterization
AU - Zolezzi, Daniela M.
AU - Alonso-Valerdi, Luz María
AU - Ibarra-Zarate, David I.
PY - 2022/5
Y1 - 2022/5
N2 - The management of chronic neuropathic pain remains a challenge, because pain is subjective, and measuring it objectively is usually out of question. However, neuropathic pain is also a signal provided by maladaptive neuronal activity. Thus, the integral management of chronic neuropathic pain should not only rely on the subjective perception of the patient, but also on objective data that measures the evolution of neuronal activity. We will discuss different objective and subjective methods for the characterization of neuropathic pain. Additionally, the gaps and proposals for an integral management of chronic neuropathic pain will also be discussed. The current management that relies mostly on subjective measures has not been sufficient, therefore, this has hindered advances in pain management and clinical trials. If an integral characterization is achieved, clinical management and stratification for clinical trials could be based on both questionnaires and neuronal activity. Appropriate characterization may lead to an increased effectiveness for new therapies, and a better quality of life for neuropathic pain sufferers.
AB - The management of chronic neuropathic pain remains a challenge, because pain is subjective, and measuring it objectively is usually out of question. However, neuropathic pain is also a signal provided by maladaptive neuronal activity. Thus, the integral management of chronic neuropathic pain should not only rely on the subjective perception of the patient, but also on objective data that measures the evolution of neuronal activity. We will discuss different objective and subjective methods for the characterization of neuropathic pain. Additionally, the gaps and proposals for an integral management of chronic neuropathic pain will also be discussed. The current management that relies mostly on subjective measures has not been sufficient, therefore, this has hindered advances in pain management and clinical trials. If an integral characterization is achieved, clinical management and stratification for clinical trials could be based on both questionnaires and neuronal activity. Appropriate characterization may lead to an increased effectiveness for new therapies, and a better quality of life for neuropathic pain sufferers.
KW - chronic neuropathic pain
KW - central nervous system
KW - somatosensory nervous system
KW - pain management
KW - neuronal oscillations
KW - neuroplasticity
KW - characterization
KW - diagnostic and evaluation questionnaires
KW - EEG
KW - electrophysiology
KW - laser evoked potential
KW - somatosensory evoked potential
KW - allodynia
KW - linear and non-linear analysis of EEG
KW - patient stratification
KW - thalamocortical dysrhythmia
KW - nociception
KW - pain pathways
KW - stimulation
KW - pain experience
KW - thalamocortical loops
KW - somatosensory cortex
KW - prefrontal cortex
KW - hyperalgesia
KW - emotional processing
KW - event related desynchronization
KW - event related synchronization
KW - biosignal processing
KW - QST
KW - approximate entropy
UR - http://www.scopus.com/inward/record.url?scp=85126081454&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2022.104599
DO - 10.1016/j.neubiorev.2022.104599
M3 - Review article
SN - 0149-7634
VL - 136
JO - Neuroscience & Biobehavioral Reviews
JF - Neuroscience & Biobehavioral Reviews
M1 - 104599
ER -