TY - JOUR
T1 - Copper homeostasis and cuproptosis in cardiovascular disease therapeutics
AU - Yang, Lifang
AU - Yang, Pingping
AU - Lip, Gregory Y. H.
AU - Ren, Jun
N1 - Copyright © 2023 Elsevier Ltd. All rights reserved.
PY - 2023/9
Y1 - 2023/9
N2 - Copper (Cu) homeostasis is gaining increasing attention in human health as both Cu overload and deficiency evokes pathological changes including cardiovascular diseases (CVDs). Cu supplementation, nanocarriers, and chelators have all exhibited therapeutic promise in some human diseases, although how Cu dyshomeostasis and cuproptosis, a novel form of regulated cell death, contribute to CVD pathology remains elusive. Here, we discuss Cu dyshomeostasis and the potential role of cuproptosis in various CVDs. We evaluate underlying cellular mechanisms, aiming to provide some insights regarding the utility of targeting Cu dyshomeostasis and cuproptosis as a novel strategy in the management of CVDs.
AB - Copper (Cu) homeostasis is gaining increasing attention in human health as both Cu overload and deficiency evokes pathological changes including cardiovascular diseases (CVDs). Cu supplementation, nanocarriers, and chelators have all exhibited therapeutic promise in some human diseases, although how Cu dyshomeostasis and cuproptosis, a novel form of regulated cell death, contribute to CVD pathology remains elusive. Here, we discuss Cu dyshomeostasis and the potential role of cuproptosis in various CVDs. We evaluate underlying cellular mechanisms, aiming to provide some insights regarding the utility of targeting Cu dyshomeostasis and cuproptosis as a novel strategy in the management of CVDs.
KW - cardiovascular diseases
KW - cell death
KW - copper dyshomeostasis
KW - cuproptosis
KW - metabolic disease
KW - mitochondria
UR - http://www.scopus.com/inward/record.url?scp=85166184741&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2023.07.004
DO - 10.1016/j.tips.2023.07.004
M3 - Journal article
C2 - 37500296
SN - 0165-6147
VL - 44
SP - 573
EP - 585
JO - Trends in pharmacological sciences
JF - Trends in pharmacological sciences
IS - 9
ER -