TY - JOUR
T1 - Genetic analysis of reaction time variability
T2 - room for improvement?
AU - Kuntsi, J
AU - Frazier-Wood, A C
AU - Banaschewski, T
AU - Gill, M
AU - Miranda, A
AU - Oades, R D
AU - Roeyers, H
AU - Rothenberger, A
AU - Steinhausen, H-C
AU - van der Meere, J J
AU - Faraone, S V
AU - Asherson, P
AU - Rijsdijk, F
PY - 2013/6
Y1 - 2013/6
N2 - Increased reaction time variability (RTV) on cognitive tasks requiring a speeded response is characteristic of several psychiatric disorders. In attention deficit hyperactivity disorder (ADHD), the association with RTV is strong phenotypically and genetically, yet high RTV is not a stable impairment but shows ADHD-sensitive improvement under certain conditions, such as those with rewards. The state regulation theory proposed that the RTV difference score, which captures change from baseline to a rewarded or fast condition, specifically measures 'state regulation'. By contrast, the interpretation of RTV baseline (slow, unrewarded) scores is debated. We aimed to investigate directly the degree of phenotypic and etiological overlap between RTV baseline and RTV difference scores. Method We conducted genetic model fitting analyses on go/no-go and fast task RTV data, across task conditions manipulating rewards and event rate, from a population-based twin sample (n=1314) and an ADHD and control sibling-pair sample (n=1265).
AB - Increased reaction time variability (RTV) on cognitive tasks requiring a speeded response is characteristic of several psychiatric disorders. In attention deficit hyperactivity disorder (ADHD), the association with RTV is strong phenotypically and genetically, yet high RTV is not a stable impairment but shows ADHD-sensitive improvement under certain conditions, such as those with rewards. The state regulation theory proposed that the RTV difference score, which captures change from baseline to a rewarded or fast condition, specifically measures 'state regulation'. By contrast, the interpretation of RTV baseline (slow, unrewarded) scores is debated. We aimed to investigate directly the degree of phenotypic and etiological overlap between RTV baseline and RTV difference scores. Method We conducted genetic model fitting analyses on go/no-go and fast task RTV data, across task conditions manipulating rewards and event rate, from a population-based twin sample (n=1314) and an ADHD and control sibling-pair sample (n=1265).
U2 - 10.1017/S0033291712002061
DO - 10.1017/S0033291712002061
M3 - Journal article
C2 - 22975296
SN - 0033-2917
VL - 43
SP - 1323
EP - 1333
JO - Psychological Medicine
JF - Psychological Medicine
IS - 6
ER -