TY - JOUR
T1 - Quick guide to polyketide synthase and nonribosomal synthease genes in Fusarium
AU - Hansen, Frederik T.
AU - Sørensen, Jens L.
AU - Giese, Henriette
AU - Sondergaard, Teis E.
AU - Frandsen, Rasmus J.N.
PY - 2012/4/16
Y1 - 2012/4/16
N2 - Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.
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AB - Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.
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KW - Fusarium
KW - Nomenclature
KW - Nonribosomal peptide synthetase
KW - Polyketide synthase
KW - Secondary metabolism
UR - http://www.scopus.com/inward/record.url?scp=84859210781&partnerID=8YFLogxK
U2 - 10.1016/j.ijfoodmicro.2012.01.018
DO - 10.1016/j.ijfoodmicro.2012.01.018
M3 - Journal article
C2 - 22377171
SN - 0168-1605
VL - 155
SP - 128
EP - 136
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
IS - 3
ER -