Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study

M Alda; G Turecki; P Grof; P Cavazzoni; A Duffy; E Grof; B Ahrens; A Berghöfer; B Müller-Oerlinghausen; M Dvoráková; E Libigerová; M Vojtĕchovský; P Zvolský; R Joober; A Nilsson; H Prochazka; R W Licht; N A Rasmussen; M Schou; P Vestergaard; A Holzinger; C Schumann; K Thau; G A Rouleau

Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study

M Alda, G Turecki, P Grof, P Cavazzoni, A Duffy, E Grof, B Ahrens, A Berghöfer, B Müller-Oerlinghausen, M Dvoráková, E Libigerová, M Vojtĕchovský, P Zvolský, R Joober, A Nilsson, H Prochazka, R W Licht, N A Rasmussen, M Schou, P VestergaardA Holzinger, C Schumann, K Thau, G A Rouleau

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

Corticotropin-releasing hormone (CRH) and proenkephalin (PENK) are hypothalamic peptides involved in the stress response and hypothalamic-pituitary axis regulation. Previous research has implicated these peptides in the pathogenesis of affective disorders. In this study we investigated two polymorphisms located in the genes that code for CRH and PENK by means of association and linkage analyses. A total of 138 bipolar patients and 108 controls were included in the association study. In addition, 24 families were available for linkage analysis, including six families of probands with documented periodic positivity of dexamethasone suppression tests (DST) during remission. We found no association of bipolar disorder with either gene. Similarly, we did not find any evidence of linkage (P = 0.56 for CRH and 0.52 for PENK) in the entire sample or in the subsample of families of DST positive probands. In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000.

Original language	English
Journal	American Journal of Medical Genetics. Part C: Seminars in Medical Genetics
Volume	96
Issue number	2
Pages (from-to)	178-81
Number of pages	4
ISSN	1552-4868
Publication status	Published - 2000
Externally published	Yes

AUB Link

Search for the material in Aalborg University Library's search engine

Cite this

Alda, M., Turecki, G., Grof, P., Cavazzoni, P., Duffy, A., Grof, E., Ahrens, B., Berghöfer, A., Müller-Oerlinghausen, B., Dvoráková, M., Libigerová, E., Vojtĕchovský, M., Zvolský, P., Joober, R., Nilsson, A., Prochazka, H., Licht, R. W., Rasmussen, N. A., Schou, M., ... Rouleau, G. A. (2000). Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study. American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, 96(2), 178-81.

@article{af2fd5aa9eca4d7b82908b350a2da684,

title = "Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study",

abstract = "Corticotropin-releasing hormone (CRH) and proenkephalin (PENK) are hypothalamic peptides involved in the stress response and hypothalamic-pituitary axis regulation. Previous research has implicated these peptides in the pathogenesis of affective disorders. In this study we investigated two polymorphisms located in the genes that code for CRH and PENK by means of association and linkage analyses. A total of 138 bipolar patients and 108 controls were included in the association study. In addition, 24 families were available for linkage analysis, including six families of probands with documented periodic positivity of dexamethasone suppression tests (DST) during remission. We found no association of bipolar disorder with either gene. Similarly, we did not find any evidence of linkage (P = 0.56 for CRH and 0.52 for PENK) in the entire sample or in the subsample of families of DST positive probands. In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000.",

author = "M Alda and G Turecki and P Grof and P Cavazzoni and A Duffy and E Grof and B Ahrens and A Bergh{\"o}fer and B M{\"u}ller-Oerlinghausen and M Dvor{\'a}kov{\'a} and E Libigerov{\'a} and M Vojtĕchovsk{\'y} and P Zvolsk{\'y} and R Joober and A Nilsson and H Prochazka and Licht, {R W} and Rasmussen, {N A} and M Schou and P Vestergaard and A Holzinger and C Schumann and K Thau and Rouleau, {G A}",

year = "2000",

language = "English",

volume = "96",

pages = "178--81",

journal = "American Journal of Medical Genetics. Part C: Seminars in Medical Genetics",

issn = "1552-4868",

publisher = "Wiley",

number = "2",

}

Alda, M, Turecki, G, Grof, P, Cavazzoni, P, Duffy, A, Grof, E, Ahrens, B, Berghöfer, A, Müller-Oerlinghausen, B, Dvoráková, M, Libigerová, E, Vojtĕchovský, M, Zvolský, P, Joober, R, Nilsson, A, Prochazka, H, Licht, RW, Rasmussen, NA, Schou, M, Vestergaard, P, Holzinger, A, Schumann, C, Thau, K & Rouleau, GA 2000, 'Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study', American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, vol. 96, no. 2, pp. 178-81.

TY - JOUR

T1 - Association and linkage studies of CRH and PENK genes in bipolar disorder

T2 - a collaborative IGSLI study

AU - Alda, M

AU - Turecki, G

AU - Grof, P

AU - Cavazzoni, P

AU - Duffy, A

AU - Grof, E

AU - Ahrens, B

AU - Berghöfer, A

AU - Müller-Oerlinghausen, B

AU - Dvoráková, M

AU - Libigerová, E

AU - Vojtĕchovský, M

AU - Zvolský, P

AU - Joober, R

AU - Nilsson, A

AU - Prochazka, H

AU - Licht, R W

AU - Rasmussen, N A

AU - Schou, M

AU - Vestergaard, P

AU - Holzinger, A

AU - Schumann, C

AU - Thau, K

AU - Rouleau, G A

PY - 2000

Y1 - 2000

N2 - Corticotropin-releasing hormone (CRH) and proenkephalin (PENK) are hypothalamic peptides involved in the stress response and hypothalamic-pituitary axis regulation. Previous research has implicated these peptides in the pathogenesis of affective disorders. In this study we investigated two polymorphisms located in the genes that code for CRH and PENK by means of association and linkage analyses. A total of 138 bipolar patients and 108 controls were included in the association study. In addition, 24 families were available for linkage analysis, including six families of probands with documented periodic positivity of dexamethasone suppression tests (DST) during remission. We found no association of bipolar disorder with either gene. Similarly, we did not find any evidence of linkage (P = 0.56 for CRH and 0.52 for PENK) in the entire sample or in the subsample of families of DST positive probands. In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000.

AB - Corticotropin-releasing hormone (CRH) and proenkephalin (PENK) are hypothalamic peptides involved in the stress response and hypothalamic-pituitary axis regulation. Previous research has implicated these peptides in the pathogenesis of affective disorders. In this study we investigated two polymorphisms located in the genes that code for CRH and PENK by means of association and linkage analyses. A total of 138 bipolar patients and 108 controls were included in the association study. In addition, 24 families were available for linkage analysis, including six families of probands with documented periodic positivity of dexamethasone suppression tests (DST) during remission. We found no association of bipolar disorder with either gene. Similarly, we did not find any evidence of linkage (P = 0.56 for CRH and 0.52 for PENK) in the entire sample or in the subsample of families of DST positive probands. In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000.

M3 - Journal article

C2 - 10893493

SN - 1552-4868

VL - 96

SP - 178

EP - 181

JO - American Journal of Medical Genetics. Part C: Seminars in Medical Genetics

JF - American Journal of Medical Genetics. Part C: Seminars in Medical Genetics

IS - 2

ER -

Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study

Abstract

AUB Link

Fingerprint

Cite this