Bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine

Maryam Rahmati, Cristian Pablo Pennisi, Ali Mobasheri, Masoud Mozafari

Research output: Contribution to book/anthology/report/conference proceedingBook chapterResearchpeer-review

23 Citations (Scopus)

Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

Original languageEnglish
Title of host publicationCell Biology and Translational Medicine : Stem Cells, Bio-materials and Tissue Engineering
EditorsKursad Turksen
Number of pages17
PublisherSpringer
Publication date2018
Pages73-89
ISBN (Print)978-3-030-04184-7
ISBN (Electronic)978-3-030-04185-4
DOIs
Publication statusPublished - 2018
SeriesAdvances in Experimental Medicine and Biology
Volume1107
ISSN0065-2598

Keywords

  • Biomaterials
  • Microenvironment
  • Regenerative medicine
  • Stem cells
  • Tissue engineering

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