TY - JOUR
T1 - Electrochemistry of complex molecular and biomolecular scale entities
AU - Engelbrekt, Christian
AU - Glukhov, Dmitrii
AU - Li, Yueqi
AU - Nazmutdinov, Renat R.
AU - Tang, Jing
AU - Ulstrup, Jens
AU - Wang, Zixiao
AU - Xiao, Xinxin
AU - Yan, Jiawei
AU - Yan, Xiaomei
AU - Zinkicheva, Tamara
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/4
Y1 - 2021/4
N2 - Structural mapping of intermediate size and large molecules and biomolecules at ultra-high resolution using single-crystal electrodes and in situ scanning tunnelling microscopy continues to disclose surprising findings. In situ scanning tunnelling spectroscopy has also recently disclosed new electrochemical conductivity features at the level of the single molecule. We overview briefly elements of this development over the last few years, with focus on three recent discoveries: (1) a new packing mode of a core monolayer target thiol, the amino acid cysteine (Cys) on Au(100)-electrodes, quite different from Cys packing on Au(111)- and Au(110)-electrodes; (2) transition of a core ferrocene in situ scanning tunnelling spectroscopy probe from stochastic single-molecule to macroscopic behaviour, a concept at the heart of nanoscience; and (3) unexpected behaviour of the large molybdenum enzyme sulfite oxidase, when going from macroscopic to single-molecule electrochemistry. We compare these studies with other recent discoveries of single-molecule protein conductivity and molecular scale inorganic nanostructures.
AB - Structural mapping of intermediate size and large molecules and biomolecules at ultra-high resolution using single-crystal electrodes and in situ scanning tunnelling microscopy continues to disclose surprising findings. In situ scanning tunnelling spectroscopy has also recently disclosed new electrochemical conductivity features at the level of the single molecule. We overview briefly elements of this development over the last few years, with focus on three recent discoveries: (1) a new packing mode of a core monolayer target thiol, the amino acid cysteine (Cys) on Au(100)-electrodes, quite different from Cys packing on Au(111)- and Au(110)-electrodes; (2) transition of a core ferrocene in situ scanning tunnelling spectroscopy probe from stochastic single-molecule to macroscopic behaviour, a concept at the heart of nanoscience; and (3) unexpected behaviour of the large molybdenum enzyme sulfite oxidase, when going from macroscopic to single-molecule electrochemistry. We compare these studies with other recent discoveries of single-molecule protein conductivity and molecular scale inorganic nanostructures.
KW - Cysteine on Au(100)
KW - Scanning tunnelling spectroscopy
KW - Single-entity electrochemistry
KW - Stochastic conductivity of redox molecules
KW - Sulfite oxidase
UR - http://www.scopus.com/inward/record.url?scp=85099177671&partnerID=8YFLogxK
U2 - 10.1016/j.coelec.2020.100670
DO - 10.1016/j.coelec.2020.100670
M3 - Review article
AN - SCOPUS:85099177671
SN - 2451-9103
VL - 26
JO - Current Opinion in Electrochemistry
JF - Current Opinion in Electrochemistry
M1 - 100670
ER -