Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

Janita Bralten; Barbara Franke; Irwin Waldman; Nanda Rommelse; Catharina Hartman; Philip Asherson; Tobias Banaschewski; Richard P Ebstein; Michael Gill; Ana Miranda; Robert D Oades; Herbert Roeyers; Aribert Rothenberger; Joseph A Sergeant; Jaap Oosterlaan; Edmund Sonuga-Barke; Hans-Christoph Steinhausen; Stephen V Faraone; Jan K Buitelaar; Alejandro Arias-Vásquez

doi:10.1016/j.jaac.2013.08.020

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

Janita Bralten, Barbara Franke, Irwin Waldman, Nanda Rommelse, Catharina Hartman, Philip Asherson, Tobias Banaschewski, Richard P Ebstein, Michael Gill, Ana Miranda, Robert D Oades, Herbert Roeyers, Aribert Rothenberger, Joseph A Sergeant, Jaap Oosterlaan, Edmund Sonuga-Barke, Hans-Christoph Steinhausen, Stephen V Faraone, Jan K Buitelaar, Alejandro Arias-Vásquez

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

Abstract

Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD.

Original language	English
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	52
Issue number	11
Pages (from-to)	1204-1212.e1
ISSN	0890-8567
DOIs	https://doi.org/10.1016/j.jaac.2013.08.020
Publication status	Published - Nov 2013

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Bralten, J., Franke, B., Waldman, I., Rommelse, N., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J. A., Oosterlaan, J., Sonuga-Barke, E., Steinhausen, H.-C., Faraone, S. V., Buitelaar, J. K., & Arias-Vásquez, A. (2013). Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 52(11), 1204-1212.e1. https://doi.org/10.1016/j.jaac.2013.08.020

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title = "Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD",

abstract = "Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD.",

author = "Janita Bralten and Barbara Franke and Irwin Waldman and Nanda Rommelse and Catharina Hartman and Philip Asherson and Tobias Banaschewski and Ebstein, {Richard P} and Michael Gill and Ana Miranda and Oades, {Robert D} and Herbert Roeyers and Aribert Rothenberger and Sergeant, {Joseph A} and Jaap Oosterlaan and Edmund Sonuga-Barke and Hans-Christoph Steinhausen and Faraone, {Stephen V} and Buitelaar, {Jan K} and Alejandro Arias-V{\'a}squez",

year = "2013",

month = nov,

doi = "10.1016/j.jaac.2013.08.020",

language = "English",

volume = "52",

pages = "1204--1212.e1",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

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Bralten, J, Franke, B, Waldman, I, Rommelse, N, Hartman, C, Asherson, P, Banaschewski, T, Ebstein, RP, Gill, M, Miranda, A, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, JA, Oosterlaan, J, Sonuga-Barke, E, Steinhausen, H-C, Faraone, SV, Buitelaar, JK & Arias-Vásquez, A 2013, 'Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 52, no. 11, pp. 1204-1212.e1. https://doi.org/10.1016/j.jaac.2013.08.020

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. / Bralten, Janita; Franke, Barbara; Waldman, Irwin et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 52, No. 11, 11.2013, p. 1204-1212.e1.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

AU - Bralten, Janita

AU - Franke, Barbara

AU - Waldman, Irwin

AU - Rommelse, Nanda

AU - Hartman, Catharina

AU - Asherson, Philip

AU - Banaschewski, Tobias

AU - Ebstein, Richard P

AU - Gill, Michael

AU - Miranda, Ana

AU - Oades, Robert D

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph A

AU - Oosterlaan, Jaap

AU - Sonuga-Barke, Edmund

AU - Steinhausen, Hans-Christoph

AU - Faraone, Stephen V

AU - Buitelaar, Jan K

AU - Arias-Vásquez, Alejandro

PY - 2013/11

Y1 - 2013/11

N2 - Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD.

AB - Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD.

U2 - 10.1016/j.jaac.2013.08.020

DO - 10.1016/j.jaac.2013.08.020

M3 - Journal article

C2 - 24157394

SN - 0890-8567

VL - 52

SP - 1204-1212.e1

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 11

ER -

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

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