Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy

Thomas Lass Klitgaard; Olav Lilleholt Schjørring; Frederik Mølgaard Nielsen; Christian Sylvest Meyhoff; Marija Barbateskovic; Jørn Wetterslev; Anders Perner; Bodil Steen Rasmussen

doi:10.1186/s40560-021-00573-5

Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy

Thomas Lass Klitgaard^*, Olav Lilleholt Schjørring, Frederik Mølgaard Nielsen, Christian Sylvest Meyhoff, Marija Barbateskovic, Jørn Wetterslev, Anders Perner, Bodil Steen Rasmussen

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

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Abstract

In a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the authors for their interest in the matter. However, the authors appear to misquote findings, fail to report results for all specified analyses, do not identify all relevant trials, have post hoc changed the eligibility criteria, and have seemingly switched directions of effects in analyses of secondary outcomes. These issues have led to incorrect conclusions concerning the effects of targeted oxygen therapy in critically ill patients.

Original language	English
Article number	72
Journal	Journal of Intensive Care
Volume	9
Issue number	1
ISSN	2052-0492
DOIs	https://doi.org/10.1186/s40560-021-00573-5
Publication status	Published - 7 Dec 2021

Bibliographical note

Keywords

Critical care
Meta-analysis
Oxygen
Systematic review

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10.1186/s40560-021-00573-5Licence: CC BY 4.0

Klitgaard et al. (2021). Letter the editor - serious methodological concerns about a recently published meta-analysis on oxygen therapyFinal published version, 2 MBLicence: CC BY 4.0

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abstract = "In a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the authors for their interest in the matter. However, the authors appear to misquote findings, fail to report results for all specified analyses, do not identify all relevant trials, have post hoc changed the eligibility criteria, and have seemingly switched directions of effects in analyses of secondary outcomes. These issues have led to incorrect conclusions concerning the effects of targeted oxygen therapy in critically ill patients.",

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AU - Barbateskovic, Marija

AU - Wetterslev, Jørn

AU - Perner, Anders

AU - Rasmussen, Bodil Steen

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AB - In a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the authors for their interest in the matter. However, the authors appear to misquote findings, fail to report results for all specified analyses, do not identify all relevant trials, have post hoc changed the eligibility criteria, and have seemingly switched directions of effects in analyses of secondary outcomes. These issues have led to incorrect conclusions concerning the effects of targeted oxygen therapy in critically ill patients.

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KW - Oxygen

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Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy

Abstract

Bibliographical note

Keywords

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