Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Resumé

Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.
OriginalsprogEngelsk
Publikationsdato2011
StatusUdgivet - 2011
Udgivet eksterntJa
Begivenhed7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII - Hamburg
Varighed: 21 sep. 201124 sep. 2011
http://www.efic.org/index.asp?sub=OEHX4PUHZ063B4

Konference

Konference7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII
ByHamburg
Periode21/09/201124/09/2011
Internetadresse

Fingerprint

Diffusion Tensor Imaging
Chronic Pancreatitis
Prefrontal Cortex
Pain
Gyrus Cinguli
Brain
Anisotropy
Somatosensory Cortex
Amygdala
Chronic Pain
Magnetic Resonance Spectroscopy
Visceral Pain
Central Nervous System
Equipment and Supplies
Water

Citer dette

Frøkjær, J. B., Olesen, S. S., Gram, M., Yavarian, Y., & Drewes, A. M. (2011). Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .
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title = "Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging",
abstract = "Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.",
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Frøkjær, JB, Olesen, SS, Gram, M, Yavarian, Y & Drewes, AM 2011, 'Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging' 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, 21/09/2011 - 24/09/2011, .

Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging. / Frøkjær, Jens Brøndum; Olesen, Søren Schou; Gram, Mikkel; Yavarian, Yousef; Drewes, Asbjørn Mohr.

2011. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

TY - ABST

T1 - Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging

AU - Frøkjær, Jens Brøndum

AU - Olesen, Søren Schou

AU - Gram, Mikkel

AU - Yavarian, Yousef

AU - Drewes, Asbjørn Mohr

PY - 2011

Y1 - 2011

N2 - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

AB - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

M3 - Conference abstract for conference

ER -

Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Drewes AM. Changes of brain microstructure in patients with painful chronic pancreatitis assessed by diffusion tensor imaging. 2011. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .