Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Dong-Hwan Yun; Chi-Un Pae; Antonio Drago; Laura Mandelli; Diana De Ronchi; Ashwin A Patkar; In Ho Paik; Alessandro Serretti; Jung-Jin Kim

doi:10.4306/pi.2008.5.2.102

Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Dong-Hwan Yun, Chi-Un Pae, Antonio Drago, Laura Mandelli, Diana De Ronchi, Ashwin A Patkar, In Ho Paik, Alessandro Serretti, Jung-Jin Kim

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

Abstract

OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment.

METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C).

RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors.

CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.

Originalsprog	Engelsk
Tidsskrift	Psychiatry investigation
Vol/bind	5
Udgave nummer	2
Sider (fra-til)	102-5
Antal sider	4
ISSN	1738-3684
DOI	https://doi.org/10.4306/pi.2008.5.2.102
Status	Udgivet - jun. 2008
Udgivet eksternt	Ja

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10.4306/pi.2008.5.2.102

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title = "Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder",

abstract = "OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment.METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C).RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors.CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.",

author = "Dong-Hwan Yun and Chi-Un Pae and Antonio Drago and Laura Mandelli and {De Ronchi}, Diana and Patkar, {Ashwin A} and Paik, {In Ho} and Alessandro Serretti and Jung-Jin Kim",

year = "2008",

month = jun,

doi = "10.4306/pi.2008.5.2.102",

language = "English",

volume = "5",

pages = "102--5",

journal = "Psychiatry investigation",

issn = "1738-3684",

publisher = "Korean Neuropsychiatric Association",

number = "2",

}

TY - JOUR

T1 - Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

AU - Yun, Dong-Hwan

AU - Pae, Chi-Un

AU - Drago, Antonio

AU - Mandelli, Laura

AU - De Ronchi, Diana

AU - Patkar, Ashwin A

AU - Paik, In Ho

AU - Serretti, Alessandro

AU - Kim, Jung-Jin

PY - 2008/6

Y1 - 2008/6

N2 - OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment.METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C).RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors.CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.

AB - OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment.METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C).RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors.CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.

U2 - 10.4306/pi.2008.5.2.102

DO - 10.4306/pi.2008.5.2.102

M3 - Journal article

C2 - 20046352

SN - 1738-3684

VL - 5

SP - 102

EP - 105

JO - Psychiatry investigation

JF - Psychiatry investigation

IS - 2

ER -

Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder

Abstract

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