TY - JOUR
T1 - Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
AU - Kamand, Morad
AU - Ilieva, Mirolyuba
AU - Forsberg, Sheena Louise
AU - Thomassen, Mads
AU - Svenningsen, Åsa Fex
AU - Meyer, Morten
AU - Michel, Tanja Maria
N1 - Funding Information:
We would like to acknowledge Associate Professor Tore Bjerregaard Stage for providing RNA from TMOi001-A cells, and the Psychiatric Research Fund of the Region of Southern Denmark (Psykiatriens Forskningsfond; R36-A1784/1808 1 0861), Faculty of Health Sciences, University of Southern Denmark (SDUSF‐2016‐144‐(738)) Denmark, and the JASCHA Foundation, Denmark for financial support (6208/1808 2 0861).
Funding Information:
We would like to acknowledge Associate Professor Tore Bjerregaard Stage for providing RNA from TMOi001-A cells, and the Psychiatric Research Fund of the Region of Southern Denmark (Psykiatriens Forskningsfond; R36-A1784/1808 1 0861), Faculty of Health Sciences, University of Southern Denmark (SDUSF?2016?144?(738)) Denmark, and the JASCHA Foundation, Denmark for financial support (6208/1808 2 0861).
Publisher Copyright:
© 2020
PY - 2020/12
Y1 - 2020/12
N2 - Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a new human induced pluripotent stem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) (“FYNEN-cohort”). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.
AB - Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a new human induced pluripotent stem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) (“FYNEN-cohort”). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=85092470351&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2020.102038
DO - 10.1016/j.scr.2020.102038
M3 - Journal article
C2 - 33068890
AN - SCOPUS:85092470351
SN - 1873-5061
VL - 49
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 102038
ER -