Abstract
hnRNPs H, H' and F belong to a subfamily of the hnRNPs sharing a high degree of sequence identity. Eukaryotic expression and specific C-terminal antibodies were used to demonstrate great variation in the intracellular fate of the proteins. hnRNPs H and H' become posttranslational cleaved into C-terminal 35 kDa proteins (H(C), H'(C)) and possibly into N-terminal 22 kDa proteins. No detectable cleavage was observed for hnRNP F. hnRNP H/H' is almost exclusively localized to the nucleus of many cell types while hnRNP F varies from a predominant nuclear localization in some cells to a predominant cytoplasmic localization in other cells. The different fates may reflect differences in functional roles that so far only have included nuclear functions. The presence of significant quantities of hnRNP F in the cytoplasm of many cells indicates that it also may have a functional role here.
Udgivelsesdato: 1999-Aug-6
Udgivelsesdato: 1999-Aug-6
Originalsprog | Engelsk |
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Tidsskrift | FEBS Letters |
Vol/bind | 456 |
Udgave nummer | 2 |
Sider (fra-til) | 274-280 |
Antal sider | 6 |
ISSN | 0014-5793 |
DOI | |
Status | Udgivet - 6 aug. 1999 |
Udgivet eksternt | Ja |