Abstract
OBJECTIVE: To analyse different forms of hyperparathyroidism (for example, sporadic and multiple endocrine neoplasia type 1 (MEN 1)) by histopathology, DNA cytometry and by the presence of allele losses on chromosome 11, thereby identifying common characteristics.
MATERIAL: Enlarged glands from 26 patients with hyperparathyroidism (23 sporadic and 3 MEN 1). Cytometric assessment was made of 28 glands.
RESULTS: Nine patients had multiple gland disease and 15 had single gland disease (14 sporadic and 1 MEN 1). DNA cytometry showed that 18 (15 sporadic and all 3 MEN 1) were diploid, seven tetraploid, and two aneuploid. Two glands from one sporadic case showed different ploidy patterns. Seven patients with sporadic and all three with MEN 1 hyperparathyroidism had allele losses for chromosome 11 in the analysed glands.
CONCLUSION: There were no significant differences in histopathological appearances, ploidy, or allele losses among abnormal glands from a variety of forms of hyperparathyroidism.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Surgery |
Vol/bind | 158 |
Udgave nummer | 4 |
Sider (fra-til) | 199-206 |
Antal sider | 8 |
ISSN | 1102-4151 |
Status | Udgivet - apr. 1992 |
Udgivet eksternt | Ja |