PURPOSE: The study examined if preoperative plasma D-dimer level was associated with the postoperative cumulative incidence of deep venous thrombosis in patients with colorectal cancer admitted for intended curative surgery. METHODS: In 176 consecutive patients with newly-diagnosed colorectal cancer and absence of preoperative deep venous thrombosis, we measured the preoperative plasma D-dimer levels and performed compression ultrasonography for deep venous thrombosis prior to surgery, as well as one week, one month, and one year after surgery. RESULTS: The cumulative incidence of deep venous thrombosis up to one year after surgery was 20 percent (95 percent confidence interval, 12 to 31 percent) in the positive D-dimer group compared with 5 percent (95 percent confidence interval, 2 to 12 percent) in the negative D-dimer group. The adjusted hazard ratio of deep venous thrombosis in the positive vs. the negative D-dimer group was 6.53 (95 percent confidence interval, 1.58 to 27.0). CONCLUSIONS: A positive preoperative D-dimer was associated with a higher cumulated incidence of postoperative deep venous thrombosis. D-dimer might be useful in identifying those colorectal cancer patients who fail to respond to standard prophylaxis for deep venous thrombosis.
|Status||Udgivet - 2010|
|Begivenhed||Forskningens Dag 2010 - Aalborg Sygehus - Aalborg|
Varighed: 28 okt. 2010 → 28 okt. 2010
|Konference||Forskningens Dag 2010 - Aalborg Sygehus|
|Periode||28/10/2010 → 28/10/2010|
Stender, M., Larsen, T. B., Frøkjær, J. B., Sørensen, H. T., & Thorlacius-Ussing, O. (2010). Preoperative plasma D-dimer is a predictor of one-year survival in colorectal cancer patients: a prospective clinical cohort study. Abstract fra Forskningens Dag 2010 - Aalborg Sygehus, Aalborg, .