TY - JOUR
T1 - Prognostic factors for adenoid cystic carcinoma of the head and neck
T2 - a retrospective evaluation of 96 cases
AU - Hamper, Klaus
AU - Lazar, Frank
AU - Dietel, Manfred
AU - Caselitz, Jörg
AU - Berger, Jürgen
AU - Arps, Hartmut
AU - Falkmer, Ursula
AU - Auer, Gert
AU - Seifert, Gerhard
PY - 1990/3
Y1 - 1990/3
N2 - Cases of adenoid cystic carcinomas of the salivary (n = 90) and lacrimal glands (n = 6) from the years 1965-1980 were evaluated retrospectively with regard to clinical, epidemiologic and histomorphologic parameters, and in 52 cases, nuclear DNA content was assessed using a single cell scanning cytophotometry procedure in order to determine prognostic factors. Clinical courses were poor with a high incidence of recurrences, hematogenous metastases and deaths from tumor. Histology was related to prognosis, glandular tumors showing a better prognosis than solid ones. Tumor size greater than 4 cm was correlated with an unfavorable clinical course in all cases. Cytophotometry yielded various types of histograms (7 diploid, 10 proliferative, 14 triploid, 19 atypical, 2 tetraploid). Significant correlations were found as to the time of survival, tumors with diploid histograms showing the longest intervals and those with atypical ones the shortest. Although the prognosis of adenoid cystic carcinoma remains poor, cytophotometry can offer additional prognostic information in the individual case.
AB - Cases of adenoid cystic carcinomas of the salivary (n = 90) and lacrimal glands (n = 6) from the years 1965-1980 were evaluated retrospectively with regard to clinical, epidemiologic and histomorphologic parameters, and in 52 cases, nuclear DNA content was assessed using a single cell scanning cytophotometry procedure in order to determine prognostic factors. Clinical courses were poor with a high incidence of recurrences, hematogenous metastases and deaths from tumor. Histology was related to prognosis, glandular tumors showing a better prognosis than solid ones. Tumor size greater than 4 cm was correlated with an unfavorable clinical course in all cases. Cytophotometry yielded various types of histograms (7 diploid, 10 proliferative, 14 triploid, 19 atypical, 2 tetraploid). Significant correlations were found as to the time of survival, tumors with diploid histograms showing the longest intervals and those with atypical ones the shortest. Although the prognosis of adenoid cystic carcinoma remains poor, cytophotometry can offer additional prognostic information in the individual case.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Adenoid Cystic/genetics
KW - Cell Nucleus/analysis
KW - Cell Transformation, Neoplastic
KW - Cytophotometry
KW - DNA, Neoplasm/analysis
KW - Diploidy
KW - Female
KW - Humans
KW - Lacrimal Apparatus Diseases/genetics
KW - Male
KW - Middle Aged
KW - Neoplasm Recurrence, Local
KW - Probability
KW - Prognosis
KW - Retrospective Studies
KW - Salivary Gland Neoplasms/genetics
U2 - 10.1111/j.1600-0714.1990.tb00806.x
DO - 10.1111/j.1600-0714.1990.tb00806.x
M3 - Journal article
C2 - 2160530
SN - 0904-2512
VL - 19
SP - 101
EP - 107
JO - Journal of Oral Pathology & Medicine
JF - Journal of Oral Pathology & Medicine
IS - 3
ER -