TY - JOUR
T1 - Support of association between BRD1 and both schizophrenia and bipolar affective disorder
AU - Nyegaard, Mette
AU - Severinsen, Jacob E
AU - Als, Thomas Damm
AU - Hedemand, Anne
AU - Straarup, Steen
AU - Nordentoft, Merete
AU - McQuillin, Andrew
AU - Bass, Nicholas
AU - Lawrence, Jacob
AU - Thirumalai, Srinivasa
AU - Pereira, Ana C P
AU - Kandaswamy, Radhika
AU - Lydall, Gregory J
AU - Sklar, Pamela
AU - Scolnick, Edward
AU - Purcell, Shaun
AU - Curtis, David
AU - Gurling, Hugh M D
AU - Mortensen, Preben B
AU - Mors, Ole
AU - Børglum, Anders
PY - 2010
Y1 - 2010
N2 - A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case-control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPD GWA study, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility. (c) 2009 Wiley-Liss, Inc.
AB - A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case-control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPD GWA study, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility. (c) 2009 Wiley-Liss, Inc.
U2 - 10.1002/ajmg.b.31023
DO - 10.1002/ajmg.b.31023
M3 - Journal article
SN - 1552-4841
VL - 153B
SP - 582
EP - 591
JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
ER -