TY - JOUR
T1 - Association between the Static and Dynamic Lung Function and CT-Derived Thoracic Skeletal Muscle Measurements-A Retrospective Analysis of a 12-Month Observational Follow-Up Pilot Study
AU - Brath, Mia Solholt Godthaab
AU - Alsted, Sisse Dyrman
AU - Sahakyan, Marina
AU - Mark, Esben Bolvig
AU - Frøkjær, Jens Brøndum
AU - Rasmussen, Henrik Højgaard
AU - Østergaard, Lasse Riis
AU - Christensen, Rasmus Brath
AU - Weinreich, Ulla Møller
PY - 2024/4
Y1 - 2024/4
N2 - BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) with low skeletal muscle mass and severe airway obstruction have higher mortality risks. However, the relationship between dynamic/static lung function (LF) and thoracic skeletal muscle measurements (SMM) remains unclear. This study explored patient characteristics (weight, BMI, exacerbations, dynamic/static LF, sex differences in LF and SMM, and the link between LF and SMM changes.METHODS: A retrospective analysis of a 12-month prospective follow-up study patients with stable COPD undergoing standardized treatment, covering mild to severe stages, was conducted. The baseline and follow-up assessments included computed tomography and body plethysmography.RESULTS: This study included 35 patients (17 females and 18 males). This study revealed that females had more stable LF but tended to have greater declines in SMM areas and indices than males (-5.4% vs. -1.9%, respectively), despite the fact that females were younger and had higher LF and less exacerbation than males. A multivariate linear regression showed a negative association between the inspiratory capacity/total lung capacity ratio (IC/TLC) and muscle fat area.CONCLUSIONS: The findings suggest distinct LF and BC progression patterns between male and female patients with COPD. A low IC/TLC ratio may predict increased muscle fat. Further studies are necessary to understand these relationships better.
AB - BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) with low skeletal muscle mass and severe airway obstruction have higher mortality risks. However, the relationship between dynamic/static lung function (LF) and thoracic skeletal muscle measurements (SMM) remains unclear. This study explored patient characteristics (weight, BMI, exacerbations, dynamic/static LF, sex differences in LF and SMM, and the link between LF and SMM changes.METHODS: A retrospective analysis of a 12-month prospective follow-up study patients with stable COPD undergoing standardized treatment, covering mild to severe stages, was conducted. The baseline and follow-up assessments included computed tomography and body plethysmography.RESULTS: This study included 35 patients (17 females and 18 males). This study revealed that females had more stable LF but tended to have greater declines in SMM areas and indices than males (-5.4% vs. -1.9%, respectively), despite the fact that females were younger and had higher LF and less exacerbation than males. A multivariate linear regression showed a negative association between the inspiratory capacity/total lung capacity ratio (IC/TLC) and muscle fat area.CONCLUSIONS: The findings suggest distinct LF and BC progression patterns between male and female patients with COPD. A low IC/TLC ratio may predict increased muscle fat. Further studies are necessary to understand these relationships better.
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Lung/diagnostic imaging
KW - Male
KW - Muscle, Skeletal
KW - Pilot Projects
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive/diagnostic imaging
KW - Retrospective Studies
KW - Tomography, X-Ray Computed
KW - computed tomography
KW - thorax
KW - lung function
KW - skeletal muscle
KW - COPD
UR - http://www.scopus.com/inward/record.url?scp=85188984549&partnerID=8YFLogxK
U2 - 10.3390/arm92020015
DO - 10.3390/arm92020015
M3 - Journal article
C2 - 38525774
SN - 2451-4934
VL - 92
SP - 123
EP - 144
JO - Advances in respiratory medicine
JF - Advances in respiratory medicine
IS - 2
ER -