Early intrathecal production of specific IgM and IgG antibodies and alpha-interferon in herpes simplex virus encephalitis

V. Mayer; V. Zachar; H. Schmidtmayerova; J. Hrúzik; J. Rajcáni; E. Mitrová; V. Lackovic; J. Raucina; J. Kotuliak; M. Faybik

Early intrathecal production of specific IgM and IgG antibodies and alpha-interferon in herpes simplex virus encephalitis

V. Mayer, V. Zachar, H. Schmidtmayerova, J. Hrúzik, J. Rajcáni, E. Mitrová, V. Lackovic, J. Raucina, J. Kotuliak, M. Faybik

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4 Citations (Scopus)

Abstract

A complex approach was used in order to establish non-invasively the aetiology in three cases of encephalitis presumably caused by herpes simplex virus (HSV). As indicative of brain HSV infection was considered the lowered serum to cerebrospinal fluid specific antibody ratio, which also assessed the humoral immune response within the CNS. For this purpose, during ongoing brain tissue infection, the early intrathecal (ITH) production of IgG and IgM antibodies was analysed by a differential enzyme-linked immunosorbent assay (ELISA) along with changing levels of complement-fixing (CF) antibodies in the serum and cerebrospinal fluid (CSF). Antiviral antibody (AA) response was markedly preceded by the appearance of alpha-interferon (IFN) in the serum and CSF. From the CNS biopsy and autopsy specimens one HSV-1 and one HSV-2 strain were recovered.

Original language	English
Journal	Acta Virologica
Volume	30
Issue number	2
Pages (from-to)	149-157
Number of pages	9
ISSN	0001-723X
Publication status	Published - 1986

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title = "Early intrathecal production of specific IgM and IgG antibodies and alpha-interferon in herpes simplex virus encephalitis",

abstract = "A complex approach was used in order to establish non-invasively the aetiology in three cases of encephalitis presumably caused by herpes simplex virus (HSV). As indicative of brain HSV infection was considered the lowered serum to cerebrospinal fluid specific antibody ratio, which also assessed the humoral immune response within the CNS. For this purpose, during ongoing brain tissue infection, the early intrathecal (ITH) production of IgG and IgM antibodies was analysed by a differential enzyme-linked immunosorbent assay (ELISA) along with changing levels of complement-fixing (CF) antibodies in the serum and cerebrospinal fluid (CSF). Antiviral antibody (AA) response was markedly preceded by the appearance of alpha-interferon (IFN) in the serum and CSF. From the CNS biopsy and autopsy specimens one HSV-1 and one HSV-2 strain were recovered.",

author = "V. Mayer and V. Zachar and H. Schmidtmayerova and J. Hr{\'u}zik and J. Rajc{\'a}ni and E. Mitrov{\'a} and V. Lackovic and J. Raucina and J. Kotuliak and M. Faybik",

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language = "English",

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pages = "149--157",

journal = "Acta Virologica",

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TY - JOUR

T1 - Early intrathecal production of specific IgM and IgG antibodies and alpha-interferon in herpes simplex virus encephalitis

AU - Mayer, V.

AU - Zachar, V.

AU - Schmidtmayerova, H.

AU - Hrúzik, J.

AU - Rajcáni, J.

AU - Mitrová, E.

AU - Lackovic, V.

AU - Raucina, J.

AU - Kotuliak, J.

AU - Faybik, M.

PY - 1986

Y1 - 1986

N2 - A complex approach was used in order to establish non-invasively the aetiology in three cases of encephalitis presumably caused by herpes simplex virus (HSV). As indicative of brain HSV infection was considered the lowered serum to cerebrospinal fluid specific antibody ratio, which also assessed the humoral immune response within the CNS. For this purpose, during ongoing brain tissue infection, the early intrathecal (ITH) production of IgG and IgM antibodies was analysed by a differential enzyme-linked immunosorbent assay (ELISA) along with changing levels of complement-fixing (CF) antibodies in the serum and cerebrospinal fluid (CSF). Antiviral antibody (AA) response was markedly preceded by the appearance of alpha-interferon (IFN) in the serum and CSF. From the CNS biopsy and autopsy specimens one HSV-1 and one HSV-2 strain were recovered.

AB - A complex approach was used in order to establish non-invasively the aetiology in three cases of encephalitis presumably caused by herpes simplex virus (HSV). As indicative of brain HSV infection was considered the lowered serum to cerebrospinal fluid specific antibody ratio, which also assessed the humoral immune response within the CNS. For this purpose, during ongoing brain tissue infection, the early intrathecal (ITH) production of IgG and IgM antibodies was analysed by a differential enzyme-linked immunosorbent assay (ELISA) along with changing levels of complement-fixing (CF) antibodies in the serum and cerebrospinal fluid (CSF). Antiviral antibody (AA) response was markedly preceded by the appearance of alpha-interferon (IFN) in the serum and CSF. From the CNS biopsy and autopsy specimens one HSV-1 and one HSV-2 strain were recovered.

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M3 - Journal article

C2 - 2873733

AN - SCOPUS:0022635270

SN - 0001-723X

VL - 30

SP - 149

EP - 157

JO - Acta Virologica

JF - Acta Virologica

IS - 2

ER -

Early intrathecal production of specific IgM and IgG antibodies and alpha-interferon in herpes simplex virus encephalitis

Abstract

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