Plasmon based biosensor for distinguishing different peptides mutation states

Gobind Das; Manohar Chirumamilla; Andrea Toma; Anisha Gopalakrishnan; Remo Proietti Zaccaria; Alessandro Alabastri; Marco Leoncini; Enzo Di Fabrizio

doi:10.1038/srep01792

Plasmon based biosensor for distinguishing different peptides mutation states

Gobind Das^*, Manohar Chirumamilla, Andrea Toma, Anisha Gopalakrishnan, Remo Proietti Zaccaria, Alessandro Alabastri, Marco Leoncini, Enzo Di Fabrizio

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Abstract

Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

Original language	English
Article number	1792
Journal	Scientific Reports
Volume	3
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep01792
Publication status	Published - 2013

Access to Document

10.1038/srep01792

AUB Link

Search for the material in Aalborg University Library's search engine

Cite this

@article{958a34cedf1f4cd292b3b82f2b0a592e,

title = "Plasmon based biosensor for distinguishing different peptides mutation states",

abstract = "Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.",

author = "Gobind Das and Manohar Chirumamilla and Andrea Toma and Anisha Gopalakrishnan and Zaccaria, {Remo Proietti} and Alessandro Alabastri and Marco Leoncini and {Di Fabrizio}, Enzo",

year = "2013",

doi = "10.1038/srep01792",

language = "English",

volume = "3",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Plasmon based biosensor for distinguishing different peptides mutation states

AU - Das, Gobind

AU - Chirumamilla, Manohar

AU - Toma, Andrea

AU - Gopalakrishnan, Anisha

AU - Zaccaria, Remo Proietti

AU - Alabastri, Alessandro

AU - Leoncini, Marco

AU - Di Fabrizio, Enzo

PY - 2013

Y1 - 2013

N2 - Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

AB - Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

UR - http://www.scopus.com/inward/record.url?scp=84877731961&partnerID=8YFLogxK

U2 - 10.1038/srep01792

DO - 10.1038/srep01792

M3 - Journal article

C2 - 23652645

AN - SCOPUS:84877731961

SN - 2045-2322

VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 1792

ER -

Plasmon based biosensor for distinguishing different peptides mutation states

Abstract

Access to Document

AUB Link

Other files and links

Fingerprint

Cite this