Stochastic filtering of quantitative data from STR DNA analysis

Torben Tvedebrink, Poul Svante Eriksen, Helle Smidt Mogensen, Niels Morling

Research output: Contribution to conference without publisher/journalPosterResearch

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Abstract

The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:

  • Background noise (random noise due to the apparatus used for measurements).
  • Pull-up effects (more systematic increase caused by overlap in the spectrum)
  • Stutters (peaks located four basepairs before the true peak).

We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

Original languageEnglish
Publication date2009
Number of pages1
Publication statusPublished - 2009
EventICFIS 2008 (International Conference on Forensic Inference and Statistics) - Lausanne, Switzerland
Duration: 20 Aug 200823 Aug 2008
Conference number: 7

Conference

ConferenceICFIS 2008 (International Conference on Forensic Inference and Statistics)
Number7
CountrySwitzerland
CityLausanne
Period20/08/200823/08/2008

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DNA
medicine
artifact
amplification
statistical analysis
experiment
analysis
science
health
background noise
effect

Cite this

Tvedebrink, T., Eriksen, P. S., Mogensen, H. S., & Morling, N. (2009). Stochastic filtering of quantitative data from STR DNA analysis. Poster session presented at ICFIS 2008 (International Conference on Forensic Inference and Statistics), Lausanne, Switzerland.
Tvedebrink, Torben ; Eriksen, Poul Svante ; Mogensen, Helle Smidt ; Morling, Niels. / Stochastic filtering of quantitative data from STR DNA analysis. Poster session presented at ICFIS 2008 (International Conference on Forensic Inference and Statistics), Lausanne, Switzerland.1 p.
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abstract = "The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.",
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Tvedebrink, T, Eriksen, PS, Mogensen, HS & Morling, N 2009, 'Stochastic filtering of quantitative data from STR DNA analysis', Lausanne, Switzerland, 20/08/2008 - 23/08/2008, .

Stochastic filtering of quantitative data from STR DNA analysis. / Tvedebrink, Torben; Eriksen, Poul Svante; Mogensen, Helle Smidt; Morling, Niels.

2009. Poster session presented at ICFIS 2008 (International Conference on Forensic Inference and Statistics), Lausanne, Switzerland.

Research output: Contribution to conference without publisher/journalPosterResearch

TY - CONF

T1 - Stochastic filtering of quantitative data from STR DNA analysis

AU - Tvedebrink, Torben

AU - Eriksen, Poul Svante

AU - Mogensen, Helle Smidt

AU - Morling, Niels

PY - 2009

Y1 - 2009

N2 - The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

AB - The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

M3 - Poster

ER -

Tvedebrink T, Eriksen PS, Mogensen HS, Morling N. Stochastic filtering of quantitative data from STR DNA analysis. 2009. Poster session presented at ICFIS 2008 (International Conference on Forensic Inference and Statistics), Lausanne, Switzerland.