Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

L H van Dongen; P de Goede; S Moeller; T E Eroglu; F Folke; G Gislason; M T Blom; P J M Elders; C Torp-Pedersen; H L Tan

doi:10.1016/j.resplu.2021.100167

Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

L H van Dongen, P de Goede, S Moeller, T E Eroglu, F Folke, G Gislason, M T Blom, P J M Elders, C Torp-Pedersen, H L Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without.

Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA.

Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions (P-range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients (P-range 0.13-84).

Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients.

Original language	English
Article number	100167
Journal	Resuscitation plus
Volume	8
ISSN	2666-5204
DOIs	https://doi.org/10.1016/j.resplu.2021.100167
Publication status	Published - Dec 2021

Bibliographical note

Keywords

Out-of-hospital cardiac arrest
Diabetes mellitus
Circadian rhythm
Temporal variation

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10.1016/j.resplu.2021.100167Licence: CC BY 4.0

van Dongen et al. (2021) Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetesFinal published version, 880 KBLicence: CC BY 4.0

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Cite this

@article{fa89d382f4e84a69a6c1abd8d3022266,

title = "Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes",

abstract = "Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without.Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA.Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions (P-range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients (P-range 0.13-84).Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients.",

keywords = "Out-of-hospital cardiac arrest, Diabetes mellitus, Circadian rhythm, Temporal variation",

author = "{van Dongen}, {L H} and {de Goede}, P and S Moeller and Eroglu, {T E} and F Folke and G Gislason and Blom, {M T} and Elders, {P J M} and C Torp-Pedersen and Tan, {H L}",

note = "{\textcopyright} 2021 The Authors.",

year = "2021",

month = dec,

doi = "10.1016/j.resplu.2021.100167",

language = "English",

volume = "8",

journal = "Resuscitation plus",

issn = "2666-5204",

publisher = "Elsevier",

}

TY - JOUR

T1 - Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

AU - van Dongen, L H

AU - de Goede, P

AU - Moeller, S

AU - Eroglu, T E

AU - Folke, F

AU - Gislason, G

AU - Blom, M T

AU - Elders, P J M

AU - Torp-Pedersen, C

AU - Tan, H L

PY - 2021/12

Y1 - 2021/12

N2 - Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without.Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA.Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions (P-range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients (P-range 0.13-84).Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients.

AB - Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without.Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA.Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions (P-range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients (P-range 0.13-84).Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients.

KW - Out-of-hospital cardiac arrest

KW - Diabetes mellitus

KW - Circadian rhythm

KW - Temporal variation

U2 - 10.1016/j.resplu.2021.100167

DO - 10.1016/j.resplu.2021.100167

M3 - Journal article

C2 - 34604822

SN - 2666-5204

VL - 8

JO - Resuscitation plus

JF - Resuscitation plus

M1 - 100167

ER -

Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

Abstract

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