Validation of Metabolic Models for Estimation of Energy Expenditure During Isolated Concentric and Eccentric Muscle Contractions

Nicki Lentz-Nielsen, Mads Daabeck Boysen, Mathias Munk-Hansen, Andreas D Laursen, Mike Steffensen, Bj Rn K Engelund, Kristoffer Iversen, Ryan G Larsen, Mark de Zee

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Abstract

Musculoskeletal modeling uses metabolic models to estimate energy expenditure of human locomotion. However, accurate estimation of energy expenditure is challenging, which may be due to uncertainty about the true energy cost of eccentric and concentric muscle contractions. The purpose of this study was to validate three commonly used metabolic models, using isolated isokinetic concentric and eccentric knee extensions/flexions. Five resistance-trained adult males (25.6 ± 2.4 year, 90.6 ± 7.5 kg, 1.81 ± 0.09 m) performed 150 repetitions at four different torques in a dynamometer. Indirect calorimetry was used to measure energy expenditure during these muscle contractions. All three models underestimated the energy expenditure (compared with indirect calorimetry) for up to 55.8% and 78.5% for concentric and eccentric contractions, respectively. Further, the coefficient of determination was in general low for eccentric contractions (R2 < 0.46) indicating increases in the absolute error with increases in load. These results show that the metabolic models perform better when predicting energy expenditure of concentric contractions compared with eccentric contractions. Thus, more knowledge about the relationship between energy expenditure and eccentric work is needed to optimize the metabolic models for musculoskeletal modeling of human locomotion.

Original languageEnglish
Article numberBIO-23-1118
JournalJournal of Biomechanical Engineering
Volume145
Issue number12
Pages (from-to)1-15
Number of pages15
ISSN0148-0731
DOIs
Publication statusPublished - 1 Dec 2023

Bibliographical note

Copyright © 2023 by ASME.

Keywords

  • Adult
  • Energy Metabolism
  • Humans
  • Locomotion
  • Male
  • Muscle Contraction/physiology
  • Muscle, Skeletal/physiology
  • metabolism
  • musculoskeletal modeling
  • validation
  • indirect calorimetry

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