Abstract
A link has been suggested between vitamin D and migraine headache; however, sufficient high-quality evidence is lacking and underlying mechanisms are yet to be determined. In addition, several interventional studies using vitamin D supplementation have yielded promising results, in particular for those patients with low serum levels of vitamin D and in pediatric migraines. This chapter presents the available evidence on the relationship between vitamin D and migraine, highlighting examples of interventional studies with vitamin D supplementation, and potential mechanisms underlying the beneficial effects of the supplementation. In addition, current limitations and suggestions for future basic and clinical investigations to optimize the design of studies for migraine-vitamin D association are outlined, considering influencing factors, potential challenges, and recommendations.
Original language | English |
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Title of host publication | Vitamins and Minerals in Neurological Disorders |
Editors | Colin Martin, Vinood Patel, Victor Preedy |
Number of pages | 16 |
Publisher | Academic Press |
Publication date | 26 Aug 2023 |
Pages | 323-338 |
Chapter | 20 |
ISBN (Print) | 9780323898355 |
ISBN (Electronic) | 9780323915724 |
DOIs | |
Publication status | Published - 26 Aug 2023 |
Keywords
- 25(OH)D
- Analgesic
- Migraine
- Pain
- Pediatric migraine
- Primary headaches
- Supplementation
- Vitamin D