TY - JOUR
T1 - Morphology and morphometry of the ulnar nerve in the forelimb of pigs
AU - Andreis, Felipe Rettore
AU - Metcalfe, Benjamin
AU - Janjua, Taha Al Muhammadee
AU - Fazan, Valéria Paula Sassoli
AU - Jensen, Winnie
AU - Meijs, Suzan
AU - Nielsen, Thomas Gomes Nørgaard Dos Santos
N1 - © 2023 The Authors. Anatomia, Histologia, Embryologia published by Wiley-VCH GmbH.
PY - 2024/1
Y1 - 2024/1
N2 - The knowledge of the morphology and morphometry of peripheral nerves is essential for developing neural interfaces and understanding nerve regeneration in basic and applied research. Currently, the most adopted animal model is the rat, even though recent studies have suggested that the neuroanatomy of large animal models is more comparable to humans. The present knowledge of the morphological structure of large animal models is limited; therefore, the present study aims to describe the morphological characteristics of the Ulnar Nerve (UN) in pigs. UN cross-sections were taken from seven Danish landrace pigs at three distinct locations: distal UN, proximal UN and at the dorsal cutaneous branch of the UN (DCBUN). The nerve diameter, fascicle diameter and number, number of fibres and fibre size were quantified. The UN diameter was larger in the proximal section compared to the distal segment and the DCBUN. The proximal branch also had a more significant number of fascicles (median: 15) than the distal (median: 10) and the DCBUN (median: 11) segments. Additionally, the mean fascicle diameter was smaller at the DCBUN (mean: 165 μm) than at the distal (mean: 197 μm) and proximal (mean: 199 μm) segments of the UN. Detailed knowledge of the microscopical structure of the UN in pigs is critical for further studies investigating neural interface designs and computational models of the peripheral nervous system.
AB - The knowledge of the morphology and morphometry of peripheral nerves is essential for developing neural interfaces and understanding nerve regeneration in basic and applied research. Currently, the most adopted animal model is the rat, even though recent studies have suggested that the neuroanatomy of large animal models is more comparable to humans. The present knowledge of the morphological structure of large animal models is limited; therefore, the present study aims to describe the morphological characteristics of the Ulnar Nerve (UN) in pigs. UN cross-sections were taken from seven Danish landrace pigs at three distinct locations: distal UN, proximal UN and at the dorsal cutaneous branch of the UN (DCBUN). The nerve diameter, fascicle diameter and number, number of fibres and fibre size were quantified. The UN diameter was larger in the proximal section compared to the distal segment and the DCBUN. The proximal branch also had a more significant number of fascicles (median: 15) than the distal (median: 10) and the DCBUN (median: 11) segments. Additionally, the mean fascicle diameter was smaller at the DCBUN (mean: 165 μm) than at the distal (mean: 197 μm) and proximal (mean: 199 μm) segments of the UN. Detailed knowledge of the microscopical structure of the UN in pigs is critical for further studies investigating neural interface designs and computational models of the peripheral nervous system.
KW - nerve morphology
KW - peripheral nerves
KW - peripheral nervous system
KW - pig
KW - ulnar nerve
UR - http://www.scopus.com/inward/record.url?scp=85171382274&partnerID=8YFLogxK
U2 - 10.1111/ahe.12972
DO - 10.1111/ahe.12972
M3 - Journal article
C2 - 37715494
SN - 0340-2096
VL - 53
JO - Anatomia, histologia, embryologia
JF - Anatomia, histologia, embryologia
IS - 1
M1 - e12972
ER -