Additional file 1: of Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

  • Line Engelbrechtsen (Ophavsperson)
  • Yuvaraj Mahendran (Bidrager)
  • Anna Jonsson (Ophavsperson)
  • Anette Prior Gjesing (Ophavsperson)
  • Peter E Weeke (Ophavsperson)
  • Marit E Jørgensen (Ophavsperson)
  • Kristine Faerch (Ophavsperson)
  • Daniel R Witte (Ophavsperson)
  • Jens J Holst (Ophavsperson)
  • Torben Jørgensen (Aalborg University, University of Copenhagen, Research Centre for Prevention and Health, The Capital Region of Denmark) (Ophavsperson)
  • Niels Grarup (Ophavsperson)
  • Oluf Pedersen (Ophavsperson)
  • Henrik Vestergaard (Ophavsperson)
  • Signe Torekov (Ophavsperson)
  • Jørgen K. Kanters (Ophavsperson)
  • Torben Hansen (Ophavsperson)

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Calculations of AUC and iAUC. Information on how AUC and iAUC was calculated in the cohorts. Table S1: Participant characteristics in the ADDITION-PRO cohort and Inter99. Anthropometric measures of individuals in the ADDITION-PRO and Inter99 cohort. Table S2. Association of variants (rs36210421 and rs1805123) with QT interval and with metabolic and incretin levels in the Inter99 cohort (n = 5487). Table with measures of QTcF interval and glucose levels in the Inter99 cohort sorted by genetic variant and combined in a genetic risk score. Table S3. Association of KCNH2 variant rs36210421 with metabolic and incretin levels in ADDITION-PRO cohort (N = 1324) (Non diabetes and newly diagnosed T2D). Table with measures of glucose, insulin GIP, GLP-1 and glucagon levels according to carrier status for rs1805123 and rs36210421. Figure S1. Levels of incretins and glucagon according to number of risk alleles. Levels of GLP-1, GIP and Glucagon during an OGTT according to number of risk alleles in the GRS. (DOCX 122 kb)
Dato for tilgængelighed2018
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