TY - JOUR
T1 - Amiodarone treatment in atrial fibrillation and the risk of incident cancers
T2 - a nationwide observational study
AU - Rasmussen, Peter Vibe
AU - Dalgaard, Frederik
AU - Gislason, Gunnar Hilmar
AU - Torp-Pedersen, Christian
AU - Piccini, Jonathan
AU - D'Souza, Maria
AU - Ruwald, Martin H
AU - Pallisgaard, Jannik Langtved
AU - Hansen, Morten Lock
N1 - Copyright © 2019 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Background: In observational studies, case reports, and animal studies, amiodarone has been associated with incident cancer. Objective: The purpose of this study was to examine whether a dose–response relationship between amiodarone use and the risk of cancer could be ascertained in a large nationwide study cohort. Methods: Using nationwide registers, we included all Danish patients with atrial fibrillation (AF) treated with amiodarone from 1996 to 2014. Exposure was defined both by categories and as a continuous variable of the cumulative defined daily doses (cDDDs) of amiodarone. The associations between amiodarone cDDD and incident cancer, as well as organ-specific types of cancer (skin, liver, lung), were estimated using multivariable Cox regression models and reported as hazard ratios (HR) with 95% confidence intervals (CI) and using cubic restricted spline plots. Results: We included 18,503 patients with a median follow-up time of 8.1 years (interquartile range [IQR] 4.3–12.4). Median age was 70 years (IQR 63–77). A total of 2974 individuals developed cancer during follow-up. We found no association between increasing amiodarone exposure (cDDD 181–400 and cDDD >400) and the hazard of incident cancer (HR 0.95; 95% CI 0.87–1.04; and HR 1.01; 95% CI 0.92–1.10) with reference to patients with cDDD <181. Similar results were found when investigating specific cancer types (skin, liver, and lung) as well as cDDD as a continuous variable. Conclusion: In a large nationwide cohort of AF patients treated with amiodarone, we found no evidence of a dose–response relationship between cumulative dose of amiodarone and incident cancer risk.
AB - Background: In observational studies, case reports, and animal studies, amiodarone has been associated with incident cancer. Objective: The purpose of this study was to examine whether a dose–response relationship between amiodarone use and the risk of cancer could be ascertained in a large nationwide study cohort. Methods: Using nationwide registers, we included all Danish patients with atrial fibrillation (AF) treated with amiodarone from 1996 to 2014. Exposure was defined both by categories and as a continuous variable of the cumulative defined daily doses (cDDDs) of amiodarone. The associations between amiodarone cDDD and incident cancer, as well as organ-specific types of cancer (skin, liver, lung), were estimated using multivariable Cox regression models and reported as hazard ratios (HR) with 95% confidence intervals (CI) and using cubic restricted spline plots. Results: We included 18,503 patients with a median follow-up time of 8.1 years (interquartile range [IQR] 4.3–12.4). Median age was 70 years (IQR 63–77). A total of 2974 individuals developed cancer during follow-up. We found no association between increasing amiodarone exposure (cDDD 181–400 and cDDD >400) and the hazard of incident cancer (HR 0.95; 95% CI 0.87–1.04; and HR 1.01; 95% CI 0.92–1.10) with reference to patients with cDDD <181. Similar results were found when investigating specific cancer types (skin, liver, and lung) as well as cDDD as a continuous variable. Conclusion: In a large nationwide cohort of AF patients treated with amiodarone, we found no evidence of a dose–response relationship between cumulative dose of amiodarone and incident cancer risk.
KW - Amiodarone
KW - Arrhythmia
KW - Atrial fibrillation
KW - Cancer
KW - Epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85078626376&partnerID=8YFLogxK
U2 - 10.1016/j.hrthm.2019.11.025
DO - 10.1016/j.hrthm.2019.11.025
M3 - Journal article
C2 - 31790830
SN - 1547-5271
VL - 17
SP - 560
EP - 566
JO - Heart Rhythm
JF - Heart Rhythm
IS - 4
ER -