TY - JOUR
T1 - Case report
T2 - Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton's agammaglobulinemia
AU - Rise, Nina
AU - Touborg, Toke
AU - Lundsted, Ditte Helene
AU - Dalager-Pedersen, Michael
AU - Mogensen, Trine H.
N1 - Copyright © 2022 Rise, Touborg, Lundsted, Dalager-Pedersen and Mogensen.
PY - 2022/11/24
Y1 - 2022/11/24
N2 - Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, who acquired SARS-CoV-2 infection and experienced a protracted disease course with 47 days of SARS-CoV-2 positivity, critical COVID-19 with respiratory insufficiency necessitating intensive care and ventilatory support, and prompting repeated intensified treatments with remdesivir, dexamethasone, and monoclonal antibodies to eventually control infection. We describe the disease course and treatment and review the current literature on COVID-19 susceptibility and evidence for vaccine efficacy in patients with XLA.
AB - Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, who acquired SARS-CoV-2 infection and experienced a protracted disease course with 47 days of SARS-CoV-2 positivity, critical COVID-19 with respiratory insufficiency necessitating intensive care and ventilatory support, and prompting repeated intensified treatments with remdesivir, dexamethasone, and monoclonal antibodies to eventually control infection. We describe the disease course and treatment and review the current literature on COVID-19 susceptibility and evidence for vaccine efficacy in patients with XLA.
KW - Adult
KW - Agammaglobulinemia/complications
KW - COVID-19
KW - Disease Progression
KW - Genetic Diseases, X-Linked/complications
KW - Humans
KW - Male
KW - SARS-CoV-2
KW - Bruton’s agammaglobulinemia
KW - inborn error of immunity
KW - viral Evolution
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85143418997&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.1057065
DO - 10.3389/fimmu.2022.1057065
M3 - Journal article
C2 - 36505407
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1057065
ER -