TY - JOUR
T1 - Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark
AU - Kaspersen, Kathrine Agergård
AU - Hindhede, Lotte
AU - Boldsen, Jens Kjærgaard
AU - Mikkelsen, Susan
AU - Vestergaard, Lasse Skafte
AU - Berthelsen, Ann-Sofie Nicole
AU - Moustsen-Helms, Ida Rask
AU - Holm, Dorte Kinggaard
AU - Nilsson, Anna Christine
AU - Sækmose, Susanne Gjørup
AU - Sørensen, Erik
AU - Harritshøj, Lene Holm
AU - Aagaard, Bitten
AU - Hjalgrim, Henrik
AU - Lillevang, Søren Thue
AU - Jørgensen, Charlotte Sværke
AU - Krause, Tyra Grove
AU - Ullum, Henrik
AU - Pedersen, Ole Birger Vestager
AU - Ostrowski, Sisse Rye
AU - Erikstrup, Christian
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2022/1/15
Y1 - 2022/1/15
N2 - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.
AB - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.
KW - SARS-CoV-2
KW - blood donors
KW - infection fatality rate
KW - seroprevalence
UR - http://www.scopus.com/inward/record.url?scp=85123721812&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab566
DO - 10.1093/infdis/jiab566
M3 - Journal article
C2 - 34788834
SN - 0022-1899
VL - 225
SP - 219
EP - 228
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
M1 - jiab566
ER -