Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

Catherine P Bondonno; Nicola P Bondonno; Frederik Dalgaard; Kevin Murray; Samantha L Gardener; Ralph N Martins; Stephanie R Rainey-Smith; Aedín Cassidy; Joshua R Lewis; Kevin D Croft; Cecilie Kyrø; Gunnar Gislason; Augustin Scalbert; Anne Tjønneland; Kim Overvad; Jonathan M Hodgson

doi:10.1002/trc2.12175

Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

Catherine P Bondonno^*, Nicola P Bondonno, Frederik Dalgaard, Kevin Murray, Samantha L Gardener, Ralph N Martins, Stephanie R Rainey-Smith, Aedín Cassidy, Joshua R Lewis, Kevin D Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M Hodgson

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Abstract

Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.

Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.

Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.

Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

Originalsprog	Engelsk
Artikelnummer	e12175
Tidsskrift	Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI)
Vol/bind	7
Udgave nummer	1
Antal sider	16
ISSN	2352-8737
DOI	https://doi.org/10.1002/trc2.12175
Status	Udgivet - 2021

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10.1002/trc2.12175Licens: CC BY-NC-ND 4.0

Bondonno et al (2021) Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohortForlagets udgivne version, 2,28 MBLicens: CC BY-NC-ND 4.0

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Citationsformater

Bondonno, C. P., Bondonno, N. P., Dalgaard, F., Murray, K., Gardener, S. L., Martins, R. N., Rainey-Smith, S. R., Cassidy, A., Lewis, J. R., Croft, K. D., Kyrø, C., Gislason, G., Scalbert, A., Tjønneland, A., Overvad, K., & Hodgson, J. M. (2021). Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI), 7(1), Artikel e12175. https://doi.org/10.1002/trc2.12175

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title = "Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort",

abstract = "Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in {"}ever{"} smokers than in {"}never{"} smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in {"}ever{"} smokers and those who were {"}normal{"} to {"}overweight{"} versus {"}never{"} smokers or those who were {"}obese,{"} respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.",

author = "Bondonno, {Catherine P} and Bondonno, {Nicola P} and Frederik Dalgaard and Kevin Murray and Gardener, {Samantha L} and Martins, {Ralph N} and Rainey-Smith, {Stephanie R} and Aed{\'i}n Cassidy and Lewis, {Joshua R} and Croft, {Kevin D} and Cecilie Kyr{\o} and Gunnar Gislason and Augustin Scalbert and Anne Tj{\o}nneland and Kim Overvad and Hodgson, {Jonathan M}",

note = "{\textcopyright} 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.",

year = "2021",

doi = "10.1002/trc2.12175",

language = "English",

volume = "7",

journal = "Alzheimer{\textquoteright}s & Dementia: Translational Research & Clinical Interventions (TRCI)",

issn = "2352-8737",

publisher = "Wiley",

number = "1",

}

Bondonno, CP, Bondonno, NP, Dalgaard, F, Murray, K, Gardener, SL, Martins, RN, Rainey-Smith, SR, Cassidy, A, Lewis, JR, Croft, KD, Kyrø, C, Gislason, G, Scalbert, A, Tjønneland, A, Overvad, K & Hodgson, JM 2021, 'Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort', Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI), bind 7, nr. 1, e12175. https://doi.org/10.1002/trc2.12175

TY - JOUR

T1 - Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

AU - Bondonno, Catherine P

AU - Bondonno, Nicola P

AU - Dalgaard, Frederik

AU - Murray, Kevin

AU - Gardener, Samantha L

AU - Martins, Ralph N

AU - Rainey-Smith, Stephanie R

AU - Cassidy, Aedín

AU - Lewis, Joshua R

AU - Croft, Kevin D

AU - Kyrø, Cecilie

AU - Gislason, Gunnar

AU - Scalbert, Augustin

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Hodgson, Jonathan M

PY - 2021

Y1 - 2021

N2 - Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

AB - Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

U2 - 10.1002/trc2.12175

DO - 10.1002/trc2.12175

M3 - Journal article

C2 - 34027025

SN - 2352-8737

VL - 7

JO - Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI)

JF - Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI)

IS - 1

M1 - e12175

ER -

Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

Abstract

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