TY - JOUR
T1 - Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases
T2 - Workshop Proceedings
AU - Mastracci, Teresa L.
AU - Apte, Minoti
AU - Amundadottir, Laufey T.
AU - Alvarsson, Alexandra
AU - Artandi, Steven
AU - Bellin, Melena D.
AU - Bernal-Mizrachi, Ernesto
AU - Caicedo, Alejandro
AU - Campbell-Thompson, Martha
AU - Cruz-Monserrate, Zobeida
AU - El Ouaamari, Abdelfattah
AU - Gaulton, Kyle J.
AU - Geisz, Andrea
AU - Goodarzi, Mark O.
AU - Hara, Manami
AU - Hull-Meichle, Rebecca L.
AU - Kleger, Alexander
AU - Klein, Alison P.
AU - Kopp, Janel L.
AU - Kulkarni, Rohit N.
AU - Muzumdar, Mandar D.
AU - Naren, Anjaparavanda P.
AU - Oakes, Scott A.
AU - Olesen, Søren S.
AU - Phelps, Edward A.
AU - Powers, Alvin C.
AU - Stabler, Cherie L.
AU - Tirkes, Temel
AU - Whitcomb, David C.
AU - Yadav, Dhiraj
AU - Yong, Jing
AU - Zaghloul, Norann A.
AU - Sander, Maike
AU - Pandol, Stephen J.
N1 - Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine-endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
AB - The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine-endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
KW - Humans
KW - Diabetes Mellitus/therapy
KW - Islets of Langerhans/metabolism
KW - Pancreas/metabolism
KW - Pancreas, Exocrine/metabolism
KW - Pancreatic Diseases/diagnosis
U2 - 10.1097/MPA.0000000000002170
DO - 10.1097/MPA.0000000000002170
M3 - Journal article
C2 - 37078927
SN - 0885-3177
VL - 51
SP - 1061
EP - 1073
JO - Pancreas
JF - Pancreas
IS - 9
ER -